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dc.contributor.authorFitzgerald, M.-
dc.contributor.authorHodgetts, S.-
dc.contributor.authorVan Den Heuvel, C.-
dc.contributor.authorNatoli, R.-
dc.contributor.authorHart, N.-
dc.contributor.authorValter, K.-
dc.contributor.authorHarvey, A.-
dc.contributor.authorVink, R.-
dc.contributor.authorProvis, J.-
dc.contributor.authorDunlop, S.-
dc.identifier.citationReviews in the Neurosciences, 2013; 24(2):205-226-
dc.description.abstractIrradiation in the red/near-infrared spectrum (R/NIR, 630–1000 nm) has been used to treat a wide range of clinical conditions, including disorders of the central nervous system (CNS), with several clinical trials currently underway for stroke and macular degeneration. However, R/NIR irradiation therapy (R/NIR-IT) has not been widely adopted in clinical practice for CNS injury or disease for a number of reasons, which include the following. The mechanism/s of action and implications of penetration have not been thoroughly addressed. The large range of treatment intensities, wavelengths and devices that have been assessed make comparisons difficult, and a consensus paradigm for treatment has not yet emerged. Furthermore, the lack of consistent positive outcomes in randomised controlled trials, perhaps due to sub-optimal treatment regimens, has contributed to scepticism. This review provides a balanced précis of outcomes described in the literature regarding treatment modalities and efficacy of R/NIR-IT for injury and disease in the CNS. We have addressed the important issues of specification of treatment parameters, penetration of R/NIR irradiation to CNS tissues and mechanism/s, and provided the necessary detail to demonstrate the potential of R/NIR-IT for the treatment of retinal degeneration, damage to white matter tracts of the CNS, stroke and Parkinson’s disease.-
dc.description.statementofresponsibilityMelinda Fitzgerald, Stuart Hodgetts, Corinna Van Den Heuvel, Riccardo Natoli, Nathan S. Hart, Krisztina Valter, Alan R. Harvey, Robert Vink, Jan Provis, Sarah A. Dunlop-
dc.publisherFreund & Pettman Publishers-
dc.rightsCopyright status unknown-
dc.subjectirradiation therapy-
dc.subjectParkinson’s disease-
dc.subjectretinal degeneration-
dc.subjecttrauma – nervous system-
dc.titleRed/near-infrared irradiation therapy for treatment of central nervous system injuries and disorders-
dc.typeJournal article-
dc.identifier.orcidVan Den Heuvel, C. [0000-0003-0664-8935]-
dc.identifier.orcidVink, R. [0000-0002-4885-0667]-
Appears in Collections:Aurora harvest 4
Pathology publications

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