Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/7920
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKind, K.en
dc.contributor.authorOwens, J.en
dc.contributor.authorLok, F.en
dc.contributor.authorRobinson, J.en
dc.contributor.authorQuinn, K.en
dc.contributor.authorMundy, L.en
dc.contributor.authorGilmour, R.en
dc.contributor.authorOwens, P.en
dc.date.issued1996en
dc.identifier.citationAmerican Journal of Physiology. Regulatory Integrative and Comparative Physiology, 1996; 271(6):R1632-R1637en
dc.identifier.issn0002-9513en
dc.identifier.issn1522-1490en
dc.identifier.urihttp://hdl.handle.net/2440/7920-
dc.description.abstractLiver contains the highest concentrations of insulin-like growth factor (IGF) I mRNA in adult rats and sheep and is a major source of circulating IGF-I. In rats, inhibition of hepatic IGF-I production by exogenous IGF-I has been reported. In fetal sheep, skeletal muscle and liver are major sites of IGF-I synthesis and potential sources of circulating IGF-I. To determine whether feedback inhibition of IGF gene expression in fetal liver or muscle by IGF-I occurs, IGF-I and IGF-II mRNAs were measured in these tissues after intravenous infusion of recombinant human IGF-I into fetal sheep. Infusion of IGF-I (26 +/- 4 micrograms.h-1.kg-1; n = 6) or saline (n = 6) commenced on day 120 of pregnancy (term = 150 days) and continued for 10 days. Plasma concentrations of IGF-I were threefold higher in infused fetuses at 130 days of gestation (P < 0.0003), whereas those of IGF-II were unchanged. IGF-I infusion reduced the relative abundance of IGF-I mRNA (P < 0.0002) and IGF-II mRNA (P < 0.01) in fetal liver by approximately 50% but did not alter IGF-I or IGF-II mRNA in skeletal muscle. These results indicate that IGF-I inhibits the expression of both IGF-I and IGF-II genes in fetal liver and that IGF gene expression in fetal liver and muscle is differentially regulated by IGF-I.en
dc.description.statementofresponsibilityKaren L. Kind, Julie A. Owens, Fong, Lok, Jeffrey S. Robinson, Kirsty J. Quinn, Linda Mundy, R. Stewart Gilmour, and Phillip C. Owensen
dc.language.isoenen
dc.publisherAmerican Physiological Societyen
dc.rightsCopyright © 1996 the American Physiological Societyen
dc.source.urihttp://ajpregu.physiology.org/content/271/6/R1632en
dc.subjectLiver; Fetal Blood; Fetus; Animals; Sheep; Humans; Insulin; Blood Glucose; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Insulin-Like Growth Factor Binding Proteins; Recombinant Proteins; RNA, Messenger; Blotting, Western; Infusions, Intravenous; Femaleen
dc.titleIntravenous infusion of insulin-like growth factor I in fetal sheep reduces hepatic IGF-I and IGF-II mRNAsen
dc.typeJournal articleen
dc.identifier.doi10.1152/ajpregu.1996.271.6.r1632en
pubs.publication-statusPublisheden
dc.identifier.orcidOwens, J. [0000-0002-7498-1353]en
dc.identifier.orcidRobinson, J. [0000-0002-4515-6039]en
Appears in Collections:Obstetrics and Gynaecology publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.