Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/79404
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Type: Journal article
Title: Ventricular and extraventricular ependymal tumors in 18 Cats
Author: Woolford, L.
de Lahunta, A.
Baiker, K.
Dobson, E.
Summers, B.
Citation: Veterinary Pathology, 2013; 50(2):243-251
Publisher: Amer Coll Vet Pathologist
Issue Date: 2013
ISSN: 0300-9858
1544-2217
Statement of
Responsibility: 
L. Woolford, A. de Lahunta, K. Baiker, E. Dobson and B.A. Summers
Abstract: Ependymal tumors are reported rarely in domestic animals. The aims of this study were to examine the clinical and pathologic features of ventricular and extraventricular ependymomas and subependymomas in 18 domestic cats examined between 1978 and 2011. Parameters examined included age, sex, breed, clinical signs, and macroscopic and histopathologic features. The mean age of affected cats was 9 years, 4 months; median age, 8.5 years. There were 8 female and 4 male cats, and 6 cats for which sex was not recorded. Breeds included 10 domestic shorthaired, 2 domestic longhaired, 1 Persian, and 1 Siamese. Clinical signs included altered mentation or behavior, seizures, circling, propulsive gait, generalized discomfort, and loss of condition. The tumors often formed intraventricular masses and usually arose from the lining of the lateral or third ventricles, followed by the fourth ventricle, mesencephalic aqueduct, and spinal cord central canal. Three tumors were extraventricular, forming masses within the cerebrum and adjacent subarachnoid space. Histologically, 15 tumors were classified as variants of ependymomas (classic, papillary, tanycytic, or clear cell) and 3 as subependymomas. Tumors were generally well demarcated; however, 6 ependymomas focally or extensively infiltrated the adjacent neural parenchyma. Characteristic perivascular pseudorosettes were observed in all ependymomas; true rosettes were less common. Some tumors had areas of necrosis, mineralization, cholesterol clefts, and/or hemorrhage. This cohort study of feline ependymal tumors includes subependymoma and primary extraventricular ependymoma, variants not previously described in the veterinary literature but well recognized in humans.
Keywords: Cat; domestic mammals; species; oncology; disease process; nervous; tissue; morphometry; technology; immunohistochemistry,technology
Rights: Copyright © 2013 by American College of Veterinary Pathologists
RMID: 0020125812
DOI: 10.1177/0300985812452580
Appears in Collections:Animal and Veterinary Sciences publications

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