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https://hdl.handle.net/2440/79534
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Type: | Journal article |
Title: | PH-responsive nutraceutical-mesoporous silica nanoconjugates with enhanced colloidal stability |
Author: | Guillet-Nicolas, R. Popat, A. Bridot, J. Monteith, G. Qiao, S. Kleitz, F. |
Citation: | Angewandte Chemie International Edition, 2013; 52(8):2318-2322 |
Publisher: | Wiley-V C H Verlag GMBH |
Issue Date: | 2013 |
ISSN: | 1433-7851 1521-3773 |
Statement of Responsibility: | Rémy Guillet-Nicolas, Amirali Popat, Jean-Luc Bridot, Gregory Monteith, Shi Zhang Qiao, and Freddy Kleitz |
Abstract: | An innovative platform for targeted oral drug delivery is proposed based on the functionalization of drug/dye-loaded mesoporous silica nanoparticles (MSNs) with a biodegradable nutraceutical (β-lactoglobulin). The attachment of the nutraceutical not only protects the drug/dye from leaching in acidic environment, but also effectively allows their release in desired basic sites (pH 7.4). |
Keywords: | β-lactoglobulin colloidal stability mesoporous silica nutraceutical oral drug delivery |
Rights: | Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
DOI: | 10.1002/anie.201208840 |
Published version: | http://dx.doi.org/10.1002/anie.201208840 |
Appears in Collections: | Aurora harvest 4 Chemical Engineering publications |
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