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Type: Journal article
Title: Effects of Streptococcus thermophilus TH-4 in a rat model of doxorrubicin-induced mucositis
Author: Wang, H.
Brook, C.
Whittaker, A.
Lawrence, A.
Yazbek, R.
Howarth, G.
Citation: Scandinavian Journal of Gastroenterology, 2013; 48(8):959-968
Publisher: Taylor & Francis As
Issue Date: 2013
ISSN: 0036-5521
Statement of
Hanru Wang, Caitlin L. Brook, Alexandra L. Whittaker, Andrew Lawrence, Roger Yazbeck and Gordon S. Howarth
Abstract: BACKGROUND: Mucositis is a debilitating intestinal side effect of chemotherapeutic regimens. Probiotics have been considered a possible preventative treatment for mucositis. Streptococcus thermophilus TH-4 (TH-4), a newly identified probiotic, has been shown to partially alleviate mucositis induced by administration of the antimetabolite chemotherapy drug, methotrexate in rats; likely mediated through a mechanism of folate production. However, its effects against other classes of chemotherapy drug have yet to be determined. Aims. The authors investigated the effects of TH-4 in a rat model of mucositis induced by the anthracycline chemotherapy drug, doxorubicin. METHODS: Gastrointestinal damage was induced in female Dark Agouti rats (148.3 ± 1.5 g) by intraperitoneal injection of doxorubicin (20 mg/kg). Animals recieved a daily oral gavage of TH-4 at 109 cfu/ml or skim milk (vehicle) from days 0 to 8. At day 6, rats were injected with either saline or doxorubicin. At kill, small intestinal tissues were collected for determination of sucrase and myeloperoxidase (MPO) activities and histological assessment. RESULTS: Body weight was significantly decreased by doxorubicin compared with normal controls (p < 0.05). Histological parameters, such as crypt depth and villus height, were also significantly decreased by doxorubicin. TH-4 partially prevented the loss of body weight induced by doxorubicin (2.3% compared with 4%), but provided no further therapeutic benefit. CONCLUSIONS: The minimal amelioration of doxorubicin-induced mucositis by TH-4 further supports folate production as a likely mechanism of TH-4 action against methotrexate-induced mucositis. Further studies into TH-4 are required to confirm its applicability to other conventional chemotherapy regimens.
Keywords: Cancer; chemotherapy; doxorubicin; mucositis; probiotics; Streptococcus thermophilus
Rights: © 2013 Informa Healthcare
RMID: 0020130569
DOI: 10.3109/00365521.2013.812142
Appears in Collections:Animal and Veterinary Sciences publications

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