Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/79567
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Type: Journal article
Title: The efficacy and safety of chitosan dextran gel in a burr hole neurosurgical sheep model
Author: Rajiv, S.
Harding, M.
Bassiouni, A.
Jardeleza, C.
Drilling, A.
James, C.
Ha, T.
Moratti, S.
Robinson, S.
Wormald, P.
Citation: Acta Neurochirurgica, 2013; 155(7):1361-1366
Publisher: Springer-Verlag Wien
Issue Date: 2013
ISSN: 0001-6268
0942-0940
Statement of
Responsibility: 
Sukanya Rajiv, Marguerite Harding, Ahmed Bassiouni, Camille Jardeleza, Amanda Drilling, Craig James, Thanh Ha, Steve Moratti, Simon Robinson, Peter-John Wormald
Abstract: BACKGROUND Achieving and maintaining haemostasis is of paramount importance in neurosurgery. Chitosan has been shown in both animal and human models to be significantly effective in haemostasis as well as in reducing adhesion formation. OBJECTIVES To evaluate the haemostatic potential and to study histopathological changes caused by novel chitosan dextran gel in a neurosurgical sheep model. METHOD Ten sheep underwent neurosurgical burr hole procedure. Bleeding control was tested at the level of bone, dura and brain separately with both chitosan gel and Gelfoam paste on separate burr holes. Baseline bleeding was measured at the time of injury using the Boezaart scale, and then every 2 min after the application of each agent until complete haemostasis or 10 min, whichever was earlier. Safety was assessed through MRI scans and histopathological analysis. RESULTS Mixed modeling showed no statistical difference in time to haemostasis between chitosan gel and Gelfoam paste (means of log-normalized areas under the curve were 1.3688 and 1.3196 respectively) for each burr hole (p  = 0.7768). Logistic regression modeling showed that Chitosan significantly decreased the incidence of bleeding beyond the first time point measured after application of the treatment when compared to Gelfoam (OR = 2.7, p = 0.04). Average edema volume (cm3) on post-operative MRI was 0.97 for Gelfoam and 1.11 for (p = 0.49) while average histology scores were 2.5 for Gelfoam versus 3.3 for chitosan (p = 0.32). CONCLUSION Chitosan dextran gel is an effective haemostatic agent to control bleeding in brain tissue. It is safe and nontoxic to neural tissue.
Keywords: Chitosan; dextran; neurosurgery; haemostasis; sheep; gelfoam; brain; dura
Rights: © Springer-Verlag Wien 2013
RMID: 0020130356
DOI: 10.1007/s00701-013-1767-0
Appears in Collections:Surgery publications

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