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Type: Journal article
Title: Interferon-ε protects the female reproductive tract from viral and bacterial infection
Other Titles: Interferon-epsilon protects the female reproductive tract from viral and bacterial infection
Author: Fung, K.
Mangan, N.
Cumming, H.
Horvat, J.
Mayall, J.
Stifter, S.
De Weerd, N.
Roisman, L.
Rossjohn, J.
Robertson, S.
Schjenken, J.
Parker, B.
Gargett, C.
Nguyen, H.
Carr, D.
Hansbro, P.
Hertzog, P.
Citation: Science, 2013; 339(6123):1088-1092
Publisher: Amer Assoc Advancement Science
Issue Date: 2013
ISSN: 0036-8075
Statement of
Ka Yee Fung, Niamh E. Mangan, Helen Cumming, Jay C. Horvat, Jemma R. Mayall, Sebastian A. Stifter, Nicole De Weerd, Laila C. Roisman, Jamie Rossjohn, Sarah A. Robertson, John E. Schjenken, Belinda Parker, Caroline E. Gargett, Hong P. T. Nguyen, Daniel J. Carr, Philip M. Hansbro, Paul J. Hertzog
Abstract: The innate immune system senses pathogens through pattern-recognition receptors (PRRs) that signal to induce effector cytokines, such as type I interferons (IFNs). We characterized IFN-ε as a type I IFN because it signaled via the Ifnar1 and Ifnar2 receptors to induce IFN-regulated genes. In contrast to other type I IFNs, IFN-ε was not induced by known PRR pathways; instead, IFN-ε was constitutively expressed by epithelial cells of the female reproductive tract (FRT) and was hormonally regulated. Ifn-ε–deficient mice had increased susceptibility to infection of the FRT by the common sexually transmitted infections (STIs) herpes simplex virus 2 and Chlamydia muridarum. Thus, IFN-ε is a potent antipathogen and immunoregulatory cytokine that may be important in combating STIs that represent a major global health and socioeconomic burden.
Keywords: Uterus; Vagina; Cell Line; Animals; Mice, Inbred C57BL; Humans; Mice; Chlamydia muridarum; Herpesvirus 2, Human; Chlamydia Infections; Herpes Genitalis; Interferons; Oligodeoxyribonucleotides; Poly dA-dT; Poly I-C; Estrogens; Ligands; Female; Toll-Like Receptors; HEK293 Cells
Rights: Copyright status unknown
RMID: 0020126475
DOI: 10.1126/science.1233321
Appears in Collections:Obstetrics and Gynaecology publications

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