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Type: Journal article
Title: Interferon-ε protects the female reproductive tract from viral and bacterial infection
Other Titles: Interferon-epsilon protects the female reproductive tract from viral and bacterial infection
Author: Fung, K.
Mangan, N.
Cumming, H.
Horvat, J.
Mayall, J.
Stifter, S.
De Weerd, N.
Roisman, L.
Rossjohn, J.
Robertson, S.
Schjenken, J.
Parker, B.
Gargett, C.
Nguyen, H.
Carr, D.
Hansbro, P.
Hertzog, P.
Citation: Science, 2013; 339(6123):1088-1092
Publisher: Amer Assoc Advancement Science
Issue Date: 2013
ISSN: 0036-8075
Statement of
Ka Yee Fung, Niamh E. Mangan, Helen Cumming, Jay C. Horvat, Jemma R. Mayall, Sebastian A. Stifter, Nicole De Weerd, Laila C. Roisman, Jamie Rossjohn, Sarah A. Robertson, John E. Schjenken, Belinda Parker, Caroline E. Gargett, Hong P. T. Nguyen, Daniel J. Carr, Philip M. Hansbro, Paul J. Hertzog
Abstract: The innate immune system senses pathogens through pattern-recognition receptors (PRRs) that signal to induce effector cytokines, such as type I interferons (IFNs). We characterized IFN-ε as a type I IFN because it signaled via the Ifnar1 and Ifnar2 receptors to induce IFN-regulated genes. In contrast to other type I IFNs, IFN-ε was not induced by known PRR pathways; instead, IFN-ε was constitutively expressed by epithelial cells of the female reproductive tract (FRT) and was hormonally regulated. Ifn-ε–deficient mice had increased susceptibility to infection of the FRT by the common sexually transmitted infections (STIs) herpes simplex virus 2 and Chlamydia muridarum. Thus, IFN-ε is a potent antipathogen and immunoregulatory cytokine that may be important in combating STIs that represent a major global health and socioeconomic burden.
Keywords: Uterus
Cell Line
Mice, Inbred C57BL
Chlamydia muridarum
Herpesvirus 2, Human
Chlamydia Infections
Herpes Genitalis
Poly dA-dT
Poly I-C
Toll-Like Receptors
HEK293 Cells
Rights: Copyright status unknown
DOI: 10.1126/science.1233321
Grant ID: ARC
Appears in Collections:Aurora harvest
Obstetrics and Gynaecology publications

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