Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/79613
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dc.contributor.authorFung, K.en
dc.contributor.authorMangan, N.en
dc.contributor.authorCumming, H.en
dc.contributor.authorHorvat, J.en
dc.contributor.authorMayall, J.en
dc.contributor.authorStifter, S.en
dc.contributor.authorDe Weerd, N.en
dc.contributor.authorRoisman, L.en
dc.contributor.authorRossjohn, J.en
dc.contributor.authorRobertson, S.en
dc.contributor.authorSchjenken, J.en
dc.contributor.authorParker, B.en
dc.contributor.authorGargett, C.en
dc.contributor.authorNguyen, H.en
dc.contributor.authorCarr, D.en
dc.contributor.authorHansbro, P.en
dc.contributor.authorHertzog, P.en
dc.date.issued2013en
dc.identifier.citationScience, 2013; 339(6123):1088-1092en
dc.identifier.issn0036-8075en
dc.identifier.issn1095-9203en
dc.identifier.urihttp://hdl.handle.net/2440/79613-
dc.description.abstractThe innate immune system senses pathogens through pattern-recognition receptors (PRRs) that signal to induce effector cytokines, such as type I interferons (IFNs). We characterized IFN-ε as a type I IFN because it signaled via the Ifnar1 and Ifnar2 receptors to induce IFN-regulated genes. In contrast to other type I IFNs, IFN-ε was not induced by known PRR pathways; instead, IFN-ε was constitutively expressed by epithelial cells of the female reproductive tract (FRT) and was hormonally regulated. Ifn-ε–deficient mice had increased susceptibility to infection of the FRT by the common sexually transmitted infections (STIs) herpes simplex virus 2 and Chlamydia muridarum. Thus, IFN-ε is a potent antipathogen and immunoregulatory cytokine that may be important in combating STIs that represent a major global health and socioeconomic burden.en
dc.description.statementofresponsibilityKa Yee Fung, Niamh E. Mangan, Helen Cumming, Jay C. Horvat, Jemma R. Mayall, Sebastian A. Stifter, Nicole De Weerd, Laila C. Roisman, Jamie Rossjohn, Sarah A. Robertson, John E. Schjenken, Belinda Parker, Caroline E. Gargett, Hong P. T. Nguyen, Daniel J. Carr, Philip M. Hansbro, Paul J. Hertzogen
dc.language.isoenen
dc.publisherAmer Assoc Advancement Scienceen
dc.rightsCopyright status unknownen
dc.subjectUterus; Vagina; Cell Line; Animals; Mice, Inbred C57BL; Humans; Mice; Chlamydia muridarum; Herpesvirus 2, Human; Chlamydia Infections; Herpes Genitalis; Interferons; Oligodeoxyribonucleotides; Poly dA-dT; Poly I-C; Estrogens; Ligands; Female; Toll-Like Receptors; HEK293 Cellsen
dc.titleInterferon-ε protects the female reproductive tract from viral and bacterial infectionen
dc.title.alternativeInterferon-epsilon protects the female reproductive tract from viral and bacterial infectionen
dc.typeJournal articleen
dc.identifier.rmid0020126475en
dc.identifier.doi10.1126/science.1233321en
dc.identifier.pubid20690-
pubs.library.collectionObstetrics and Gynaecology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidRobertson, S. [0000-0002-5669-4422]en
dc.identifier.orcidSchjenken, J. [0000-0001-6293-6160]en
Appears in Collections:Obstetrics and Gynaecology publications

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