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https://hdl.handle.net/2440/79639
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dc.contributor.author | Nicotra, L. | - |
dc.contributor.author | Vu, M. | - |
dc.contributor.author | Harvey, B. | - |
dc.contributor.author | Smid, S. | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Prostaglandins and Other Lipid Mediators, 2013; 100(1):22-29 | - |
dc.identifier.issn | 1098-8823 | - |
dc.identifier.issn | 2212-196X | - |
dc.identifier.uri | http://hdl.handle.net/2440/79639 | - |
dc.description.abstract | Endocannabinoids are protective in animal colitis models. As endocannabinoids also form novel prostaglandin ethanolamides (prostamides) via COX-2, we investigated the effects of prostamides and other COX-2 mediators on tissue damage in an ex vivo human mucosal explant colitis model. Healthy human colonic mucosae were incubated with pro-inflammatory cytokines TNF-α and IL-1β to elicit colitis-like tissue damage. The PGF-ethanolamide analogue, bimatoprost decreased colitis scores which were reversed by a prostamide-specific antagonist AGN 211334, but not the FP receptor antagonist AL-8810. PGF-ethanolamide and PGE-ethanolamide also reduced cytokine-evoked epithelial damage. Anandamide was protective in the explant colitis model; however COX-2 inhibition did not alter its effects, associated with a lack of COX-2 induction in explant mucosal tissue. These findings support an anti-inflammatory role for prostamides and endocannabinoids in the human colon. | - |
dc.description.statementofresponsibility | Lauren L. Nicotra, Megan Vu, Benjamin S. Harvey and Scott D. Smid | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Inc. | - |
dc.rights | © 2013 Elsevier Inc. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.prostaglandins.2013.01.003 | - |
dc.subject | Colon, Sigmoid | - |
dc.subject | Humans | - |
dc.subject | Colitis | - |
dc.subject | Amides | - |
dc.subject | Sulfonamides | - |
dc.subject | Oxazoles | - |
dc.subject | Arachidonic Acids | - |
dc.subject | Dinoprostone | - |
dc.subject | Dinoprost | - |
dc.subject | Cloprostenol | - |
dc.subject | Tumor Necrosis Factor-alpha | - |
dc.subject | Receptors, Prostaglandin | - |
dc.subject | Cyclooxygenase Inhibitors | - |
dc.subject | Endocannabinoids | - |
dc.subject | Tissue Culture Techniques | - |
dc.subject | Immunohistochemistry | - |
dc.subject | Adult | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Cyclooxygenase 2 | - |
dc.subject | Polyunsaturated Alkamides | - |
dc.subject | Interleukin-1beta | - |
dc.subject | Young Adult | - |
dc.subject | Bimatoprost | - |
dc.title | Prostaglandin ethanolamides attenuate damage in a human explant colitis model | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.prostaglandins.2013.01.003 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Smid, S. [0000-0003-4192-7219] | - |
Appears in Collections: | Aurora harvest Pharmacology publications |
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