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Type: Journal article
Title: Concise review: preclinical studies on human cell-based therapy in rodent ischemic stroke models: where are we now after a decade?
Author: Leong, W.
Lewis, M.
Koblar, S.
Citation: Stem Cells, 2013; 31(6):1040-1043
Publisher: Alphamed Press
Issue Date: 2013
ISSN: 1066-5099
Statement of
Wai Khay Leong, Martin D. Lewis and Simon A. Koblar
Abstract: Stroke, a debilitating brain insult, afflicts millions of individuals globally each year. In the last decade, researchers have investigated cell-based therapy as an alternative strategy to improve neurological outcome following stroke. This concise review critically examines preclinical reports using human adult and fetal stem/progenitor cells in rodent models of ischemic stroke. As we enter the second decade of study, we should aim to optimize our collective likelihood to translational success for stroke victims worldwide. We advocate international consensus recommendations be developed for future preclinical research.
Keywords: Cell-bsed therapy
middle cerebral artery occlusion
rat model
human stem/progenitor cells
ischemic stroke
Rights: Copyright © 2013 AlphaMed Press
DOI: 10.1002/stem.1348
Appears in Collections:Aurora harvest 4
Molecular and Biomedical Science publications

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