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Type: Journal article
Title: Aberrant lipid metabolism: an emerging diagnostic and therapeutic target in ovarian cancer
Author: Pyragius, C.
Fuller, M.
Ricciardelli, C.
Oehler, M.
Citation: International Journal of Molecular Sciences (Online), 2013; 14(4):7742-7756
Publisher: Molecular Diversity Preservation International (MDPI) AG.
Issue Date: 2013
ISSN: 1422-0067
Statement of
Carmen E. Pyragius, Maria Fuller, Carmela Ricciardelli and Martin K. Oehler
Abstract: Ovarian cancer remains the most lethal gynaecological cancer. A better understanding of the molecular pathogenesis of ovarian cancer is of critical importance to develop early detection tests and identify new therapeutic targets that would increase survival. Cancer cells depend on de novo lipid synthesis for the generation of fatty acids to meet the energy requirements for increased tumour growth. There is increasing evidence that lipid metabolism is deregulated in cancers, including ovarian cancer. The increased expression and activity of lipogenic enzymes is largely responsible for increased lipid synthesis, which is regulated by metabolic and oncogenic signalling pathways. This article reviews the latest knowledge on lipid metabolism and the alterations in the expression of lipogenic enzymes and downstream signalling pathways in ovarian cancer. Current developments for exploiting lipids as biomarkers for the detection of early stage ovarian cancer and therapeutic targets are discussed. Current research targeting lipogenic enzymes and lipids to increase the cytotoxicity of chemotherapy drugs is also highlighted.
Keywords: ovarian cancer; lipid synthesis; signalling pathways; biomarkers; therapeutic targets
Rights: © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (
RMID: 0020127950
DOI: 10.3390/ijms14047742
Appears in Collections:Obstetrics and Gynaecology publications

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