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|Title:||Effects of rectal administration of taurocholic acid on glucagon-like peptide-1 and peptide YY secretion in healthy humans|
|Citation:||Diabetes Obesity & Metabolism, 2013; 15(5):474-477|
|Publisher:||Blackwell Publishing Ltd|
|T. Wu, M. J. Bound, S. D. Standfield, B.Gedulin, K. L. Jones, M. Horowitz & C. K. Rayner|
|Abstract:||Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), secreted by enteroendocrine L-cells located most densely in the colon and rectum, are of fundamental importance in blood glucose and appetite regulation. In animal models, colonic administration of bile acids can stimulate GLP-1 and PYY by TGR5 receptor activation. We evaluated the effects of taurocholic acid (TCA), administered as an enema, on plasma GLP-1 and PYY, as well as gastrointestinal sensations in 10 healthy male subjects, and observed that rectal administration of TCA promptly stimulated secretion of both GLP-1 and PYY, and increased fullness, in a dose-dependent manner. These observations confirm that topical application of bile acids to the distal gut may have potential for the management of type 2 diabetes and obesity.|
|Keywords:||bile salt; glucagon-like peptide 1; peptide YY|
|Rights:||© 2012 Blackwell Publishing Ltd|
|Appears in Collections:||Medicine publications|
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