Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/79812
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Type: Journal article
Title: Real-time and in situ drug release monitoring from nanoporous implants under dynamic flow conditions by reflectometric interference spectroscopy
Author: Kumeria, T.
Gulati, K.
Santos, A.
Losic, D.
Citation: ACS Applied Materials and Interfaces, 2013; 5(12):5436-5442
Publisher: American Chemical Society
Issue Date: 2013
ISSN: 1944-8244
1944-8252
Statement of
Responsibility: 
Tushar Kumeria, Karan Gulati, Abel Santos, and Dusan Losic
Abstract: Herein, we present an innovative approach to monitoring in situ drug release under dynamic flow conditions from aluminum implants featuring nanoporous anodic alumina (NAA) covers used as a model of drug-releasing implants. In this method, reflectometric interference spectroscopy (RIfS) is used to monitor in real-time the diffusion of drug from these nanoporous implants. The release process is carried out in a microfluidic device, which makes it possible to analyze drug release under dynamic flow conditions with constant refreshing of eluting medium. This setup mimics the physiological conditions of biological milieu at the implant site inside the host body. The release of a model drug, indomethacin, is established by measuring the optical thickness change with time under four different flow rates (i.e. 0, 10, 30, and 50 μL min⁻¹). The obtained data are fitted by a modified Higuchi model, confirming the diffusion-controlled release mechanism. The obtained release rate constants demonstrate that the drug release depends on the flow rate and the faster the flow rate the higher the drug release from the nanoporous covers. In particular, the rate constants increase from 2.23 ± 0.02 to 12.47 ± 0.04 μg min⁻¹/² when the flow rate is increased from 10 to 50 μL min⁻¹, respectively. Therefore, this method provides more reliable and relevant information than conventional in vitro drug release methods performed under static conditions.
Keywords: nanoporous anodic alumina; drug release control; dynamic flow conditions; nanoporous implants; optical thickness
Rights: Copyright © 2013 American Chemical Society
RMID: 0020130381
DOI: 10.1021/am4013984
Grant ID: http://purl.org/au-research/grants/arc/DP120101680
http://purl.org/au-research/grants/arc/FT110100711
Appears in Collections:Chemical Engineering publications

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