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Type: Journal article
Title: Pre-eclampsia and thrombophilia
Author: Said, J.
Dekker, G.
Citation: Best Practice & Research in Clinical Obstetrics & Gynaecology, 2003; 17(3):441-458
Publisher: Bailliere Tindall
Issue Date: 2003
ISSN: 1521-6934
Abstract: Pre-eclampsia is a major cause of perinatal and maternal morbidity and mortality worldwide. Although knowledge of the precise aetiology remains uncertain a number of risk factors have been described. Thrombophilias have been associated with pre-eclampsia in a number of studies and it is biologically plausible that they may contribute to the uteroplacental thrombosis that is frequently seen in pre-eclampsia. If this association is confirmed, there is the potential to investigate preventive treatments, including low-molecular-weight heparins, aspirin and folate.
Keywords: pre-eclampsia; thrombophilia; pregnancy; thrombosis; factor V Leiden; APCR; prothrombin gene mutation; hyperhomocysteinaemia; methylenetetrahydrofolate reductase; protein S; protein C; antithrombin; low molecular weight heparin (LMWH); aspirin; folate
RMID: 0020030556
DOI: 10.1016/S1521-6934(03)00008-7
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Appears in Collections:Obstetrics and Gynaecology publications

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