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|Title:||Pre-eclampsia and thrombophilia|
|Citation:||Best Practice & Research in Clinical Obstetrics & Gynaecology, 2003; 17(3):441-458|
|Abstract:||Pre-eclampsia is a major cause of perinatal and maternal morbidity and mortality worldwide. Although knowledge of the precise aetiology remains uncertain a number of risk factors have been described. Thrombophilias have been associated with pre-eclampsia in a number of studies and it is biologically plausible that they may contribute to the uteroplacental thrombosis that is frequently seen in pre-eclampsia. If this association is confirmed, there is the potential to investigate preventive treatments, including low-molecular-weight heparins, aspirin and folate.|
|Keywords:||pre-eclampsia; thrombophilia; pregnancy; thrombosis; factor V Leiden; APCR; prothrombin gene mutation; hyperhomocysteinaemia; methylenetetrahydrofolate reductase; protein S; protein C; antithrombin; low molecular weight heparin (LMWH); aspirin; folate|
|Appears in Collections:||Obstetrics and Gynaecology publications|
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