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https://hdl.handle.net/2440/8008
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Type: | Journal article |
Title: | Pre-eclampsia and thrombophilia |
Author: | Said, J. Dekker, G. |
Citation: | Best Practice and Research: Clinical Obstetrics and Gynaecology, 2003; 17(3):441-458 |
Publisher: | Bailliere Tindall |
Issue Date: | 2003 |
ISSN: | 1521-6934 1532-1932 |
Abstract: | Pre-eclampsia is a major cause of perinatal and maternal morbidity and mortality worldwide. Although knowledge of the precise aetiology remains uncertain a number of risk factors have been described. Thrombophilias have been associated with pre-eclampsia in a number of studies and it is biologically plausible that they may contribute to the uteroplacental thrombosis that is frequently seen in pre-eclampsia. If this association is confirmed, there is the potential to investigate preventive treatments, including low-molecular-weight heparins, aspirin and folate. |
Keywords: | pre-eclampsia thrombophilia pregnancy thrombosis factor V Leiden APCR prothrombin gene mutation hyperhomocysteinaemia methylenetetrahydrofolate reductase protein S protein C antithrombin low molecular weight heparin (LMWH) aspirin folate |
DOI: | 10.1016/S1521-6934(03)00008-7 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/623004/description#description |
Published version: | http://dx.doi.org/10.1016/s1521-6934(03)00008-7 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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