Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/80095
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Type: Journal article
Title: Omega-6 polyunsaturated fatty acids and the early origins of obesity
Author: Muhlhausler, B.
Ailhaud, G.
Citation: Current Opinion in Endocrinology, Diabetes and Obesity, 2013; 20(1):56-61
Publisher: Lippincott Williams & Wilkins
Issue Date: 2013
ISSN: 1752-296X
1752-2978
Statement of
Responsibility: 
Beverly S. Muhlhausler and Gérard P. Ailhaud
Abstract: PURPOSE OF REVIEW: The incidence of obesity and its related metabolic disorders has increased significantly over the past 3 decades, culminating in the current global epidemic of metabolic disease and leading to the search for contributing factors. Exposure of the developing foetus/neonate to a typical Western diet increases their risk of obesity and metabolic disorders throughout the life-course, creating an intergenerational cycle of metabolic disease. In Western countries, this epidemic of metabolic disease has coincided with a marked increase in the intake of omega-6 polyunsaturated fatty acids (omega-6 PUFA), leading to suggestions that the two may be causally related. RECENT FINDINGS: Recent studies have emphasized the proadipogenic properties of the omega-6 PUFA, and provided evidence that rodents fed on diets with omega-6 PUFA contents similar to the typical US diet (6–8% energy) have an increased fat mass. Importantly, recent studies have shown that perinatal exposure to a high omega-6 PUFA diet results in a progressive accumulation of body fat across generations. SUMMARY: This review highlights the recent evidence supporting the role of the omega-6 PUFA in the early life origins of obesity and metabolic disease, the need for more clinical studies and the potential need for health agencies to re-evaluate current recommendations to further increase omega-6 PUFA intakes.
Keywords: Humans; Prenatal Exposure Delayed Effects; Obesity; Fatty Acids, Omega-6; Diet; Pregnancy; Adult; Child, Preschool; Infant; Infant, Newborn; Female; Male; Maternal Nutritional Physiological Phenomena
Rights: Copyright: © 2013 Wolters Kluwer Health
RMID: 0020123628
DOI: 10.1097/MED.0b013e32835c1ba7
Appears in Collections:Agriculture, Food and Wine publications

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