Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/80095
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dc.contributor.author | Muhlhausler, B. | - |
dc.contributor.author | Ailhaud, G. | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Current Opinion in Endocrinology, Diabetes and Obesity, 2013; 20(1):56-61 | - |
dc.identifier.issn | 1752-296X | - |
dc.identifier.issn | 1752-2978 | - |
dc.identifier.uri | http://hdl.handle.net/2440/80095 | - |
dc.description.abstract | PURPOSE OF REVIEW: The incidence of obesity and its related metabolic disorders has increased significantly over the past 3 decades, culminating in the current global epidemic of metabolic disease and leading to the search for contributing factors. Exposure of the developing foetus/neonate to a typical Western diet increases their risk of obesity and metabolic disorders throughout the life-course, creating an intergenerational cycle of metabolic disease. In Western countries, this epidemic of metabolic disease has coincided with a marked increase in the intake of omega-6 polyunsaturated fatty acids (omega-6 PUFA), leading to suggestions that the two may be causally related. RECENT FINDINGS: Recent studies have emphasized the proadipogenic properties of the omega-6 PUFA, and provided evidence that rodents fed on diets with omega-6 PUFA contents similar to the typical US diet (6–8% energy) have an increased fat mass. Importantly, recent studies have shown that perinatal exposure to a high omega-6 PUFA diet results in a progressive accumulation of body fat across generations. SUMMARY: This review highlights the recent evidence supporting the role of the omega-6 PUFA in the early life origins of obesity and metabolic disease, the need for more clinical studies and the potential need for health agencies to re-evaluate current recommendations to further increase omega-6 PUFA intakes. | - |
dc.description.statementofresponsibility | Beverly S. Muhlhausler and Gérard P. Ailhaud | - |
dc.language.iso | en | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.rights | Copyright: © 2013 Wolters Kluwer Health | - |
dc.source.uri | http://dx.doi.org/10.1097/med.0b013e32835c1ba7 | - |
dc.subject | Humans | - |
dc.subject | Prenatal Exposure Delayed Effects | - |
dc.subject | Obesity | - |
dc.subject | Fatty Acids, Omega-6 | - |
dc.subject | Diet | - |
dc.subject | Pregnancy | - |
dc.subject | Adult | - |
dc.subject | Child, Preschool | - |
dc.subject | Infant | - |
dc.subject | Infant, Newborn | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Maternal Nutritional Physiological Phenomena | - |
dc.title | Omega-6 polyunsaturated fatty acids and the early origins of obesity | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1097/MED.0b013e32835c1ba7 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Muhlhausler, B. [0000-0002-9021-6790] | - |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 4 |
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File | Description | Size | Format | |
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hdl_80095.pdf | Accepted version | 555.36 kB | Adobe PDF | View/Open |
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