Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/80132
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Type: Journal article
Title: Retinol-binding protein 4 is expressed in chondrocytes of developing mouse long bones: implications for a local role in formation of the secondary ossification center
Author: Hatfield, J.
Anderson, P.
Powell, B.
Citation: Histochemistry and Cell Biology, 2013; 139(5):727-734
Publisher: Springer-Verlag
Issue Date: 2013
ISSN: 0948-6143
1432-119X
Statement of
Responsibility: 
Jodie T. Hatfield, Peter J. Anderson, Barry C. Powell
Abstract: Retinol-binding protein 4 (Rbp4) is the major carrier of retinol in the bloodstream, a retinoid whose metabolites influence osteogenesis, chondrogenesis and adipogenesis. Rbp4 is mainly produced in the liver where it mobilizes hepatic retinol stores to supply other tissues. However, Rbp4 is also expressed in several extrahepatic tissues, including limbs, where its role is largely unknown. This study aimed to identify the cellular localization of Rbp4 to gain insight into its involvement in limb development and bone growth. Using immunohistochemistry, we discovered that Rbp4 was present in a variety of locations in developing embryonic and postnatal mouse hindlimbs. Rbp4 was present in a restricted population of epiphyseal chondrocytes and perichondral cells correlating to the future region of secondary ossification. With the onset of secondary ossification, Rbp4 was detected in chondrocytes of the resting zone and in chondrocytes that bordered invading cartilage canals and the expanding front of ossification. Rbp4 was less abundant in proliferating chondrocytes involved in primary ossification. Our data implicate the involvement of chondrocytic Rbp4 in bone growth, particularly in the formation of the secondary ossification center of the limb.
Keywords: Retinol-binding protein 4; Chondrocyte; Cartilage canal; Secondary ossification; Tibia; Bone
Rights: © Springer-Verlag Berlin Heidelberg 2012
RMID: 0020127903
DOI: 10.1007/s00418-012-1062-9
Appears in Collections:Dentistry publications

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