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Type: Journal article
Title: Hepatic encephalopathy associated with cancer or anticancer therapy
Author: Willson, K.
Nott, L.
Broadbridge, V.
Price, T.
Citation: Gastrointestinal cancer research : GCR, 2013; 6(1):11-16
Publisher: International Society of Gastrointestinal Oncology
Issue Date: 2013
ISSN: 1934-7820
Statement of
Kaspar J. Willson, Louise M. Nott, Vy T. Broadbridge, Timothy Price
Abstract: Hepatic encephalopathy is an uncommon cause of neurologic deterioration associated with hyperammonemia, which results from hepatic dysfunction or altered ammonia metabolism. Often overlooked, hyperammonemia may occur via any of several pathophysiological processes, and in the setting of malignancy, it is a potentially reversible cause of confusion and coma. Hepatic dysfunction as a result of malignant infiltration, chemotherapeutic toxicities, targeted anticancer therapies, reactivation hepatitis, portosystemic shunting, and transarterial chemoembolization (TACE) is discussed, and an approach to etiological diagnosis and management is outlined.
Rights: © 2013 by International Society of Gastrointestinal Oncology
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