Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/80329
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Type: Journal article
Title: β-lactam resistance in gram-negative pathogens isolated from animals
Other Titles: beta-lactam resistance in gram-negative pathogens isolated from animals
Author: Trott, D.
Citation: Current Pharmaceutical Design, 2013; 19(2):239-249
Publisher: Bentham Science Publ Ltd
Issue Date: 2013
ISSN: 1381-6128
1873-4286
Statement of
Responsibility: 
Darren Trott
Abstract: Although β-lactams remain a cornerstone of veterinary therapeutics, only a restricted number are actually approved for use in food-producing livestock in comparison to companion animals and wildlife. Nevertheless, both registered and off-label use of third and fourth-generation cephalosporins in livestock may have influenced the emergence of plasmid-encoded AmpC β-lactamases (pAmpC) (mainly CMY-2) and CTX-M extended-spectrum β-lactamases (ESBLs) in both Gram-negative pathogens and commensals isolated from animals. This presents a public health concern due to the potential risk of transfer of β-lactam-resistant pathogens from livestock to humans through food. The recent detection of pAmpC and ESBLs in multidrug-resistant Enterobacteriaceae isolated from dogs has also confirmed the public health importance of β-lactam resistance in companion animals, though in this case, human-to-animal transmission may be equally as relevant as animal-to-human transmission. Identification of pAmpC and ESBLs in Enterobacteriaceae isolated from wildlife and aquaculture species may be evidence of environmental selection pressure arising from both human and veterinary use of β- lactams. Such selection pressure in animals could be reduced by the availability of reliable alternative control measures such as vaccines, bacteriophage treatments and/or competitive exclusion models for endemic production animal diseases such as colibacillosis. The global emergence and pandemic spread of extraintestinal pathogenic E. coli O25-ST131 strains expressing CTX-M-15 ESBL in humans and its recent detection in livestock, companion animals and wildlife is a major cause for concern and goes against the paradigm that Gramnegative pathogens do not necessarily have to lose virulence in compensation for acquiring resistance.
Keywords: Escherichia coli; Extended-spectrum; ST131; antimicrobial resistance; companion animals; livestock; β-lactamases
Rights: Copyright status unknown
RMID: 0020126437
DOI: 10.2174/138161213804070339
Appears in Collections:Animal and Veterinary Sciences publications

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