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|dc.identifier.citation||Current Pharmaceutical Design, 2013; 19(2):239-249||en|
|dc.description.abstract||Although β-lactams remain a cornerstone of veterinary therapeutics, only a restricted number are actually approved for use in food-producing livestock in comparison to companion animals and wildlife. Nevertheless, both registered and off-label use of third and fourth-generation cephalosporins in livestock may have influenced the emergence of plasmid-encoded AmpC β-lactamases (pAmpC) (mainly CMY-2) and CTX-M extended-spectrum β-lactamases (ESBLs) in both Gram-negative pathogens and commensals isolated from animals. This presents a public health concern due to the potential risk of transfer of β-lactam-resistant pathogens from livestock to humans through food. The recent detection of pAmpC and ESBLs in multidrug-resistant Enterobacteriaceae isolated from dogs has also confirmed the public health importance of β-lactam resistance in companion animals, though in this case, human-to-animal transmission may be equally as relevant as animal-to-human transmission. Identification of pAmpC and ESBLs in Enterobacteriaceae isolated from wildlife and aquaculture species may be evidence of environmental selection pressure arising from both human and veterinary use of β- lactams. Such selection pressure in animals could be reduced by the availability of reliable alternative control measures such as vaccines, bacteriophage treatments and/or competitive exclusion models for endemic production animal diseases such as colibacillosis. The global emergence and pandemic spread of extraintestinal pathogenic E. coli O25-ST131 strains expressing CTX-M-15 ESBL in humans and its recent detection in livestock, companion animals and wildlife is a major cause for concern and goes against the paradigm that Gramnegative pathogens do not necessarily have to lose virulence in compensation for acquiring resistance.||en|
|dc.publisher||Bentham Science Publ Ltd||en|
|dc.rights||Copyright status unknown||en|
|dc.subject||Escherichia coli; Extended-spectrum; ST131; antimicrobial resistance; companion animals; livestock; β-lactamases||en|
|dc.title||β-lactam resistance in gram-negative pathogens isolated from animals||en|
|dc.title.alternative||beta-lactam resistance in gram-negative pathogens isolated from animals||en|
|pubs.library.collection||Animal and Veterinary Sciences publications||en|
|dc.identifier.orcid||Trott, D. [0000-0002-8297-5770]||en|
|Appears in Collections:||Animal and Veterinary Sciences publications|
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