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dc.contributor.authorMarathe, C.en
dc.contributor.authorRayner, C.en
dc.contributor.authorJones, K.en
dc.contributor.authorHorowitz, M.en
dc.identifier.citationPeptides, 2013; 44:75-86en
dc.description.abstractThe gut derived peptides, glucagon-like peptides 1 and 2 (GLP-1 and GLP-2), are secreted following nutrient ingestion. GLP-1 and another gut peptide, glucose-dependent insulinotropic polypeptide (GIP) are collectively referred to as 'incretin' hormones, and play an important role in glucose homeostasis. Incretin secretion shares a complex interdependent relationship with both postprandial glycemia and the rate of gastric emptying. GLP-1 based therapies are now well established in the management of type 2 diabetes, while recent literature has suggested potential applications to treat obesity and protect against cardiovascular and neurological disease. The mechanism of action of GLP-2 is not well understood, but it shows promise as an intestinotropic agent.en
dc.description.statementofresponsibilityChinmay S. Marathe, Christopher K. Rayner, Karen L. Jones, Michael Horowitzen
dc.publisherElsevier Science Incen
dc.rights© 2013 Elsevier Inc. All rights reserved.en
dc.subjectPancreas; Animals; Humans; Diabetes Mellitus, Type 2; Blood Glucose; Receptors, Glucagon; Gastric Emptying; Postprandial Period; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Clinical Trials as Topic; Incretinsen
dc.titleGlucagon-like peptides 1 and 2 in health and disease: A reviewen
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidRayner, C. [0000-0002-5527-256X]en
dc.identifier.orcidJones, K. [0000-0002-1155-5816]en
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
Appears in Collections:Medicine publications

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