Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/80409
Type: Thesis
Title: [Uncovering the critical roles of magnesium and substance P in central nervous system injury].
Author: Vink, Robert
Issue Date: 2013
School/Discipline: School of Molecular and Biomedical Science
Abstract: Dot Point Summary . First to apply phosphorus magnetic resonance spectroscopy to the study of traumatic brain injury (TBl) and spinal cord injury (SCl) - led to a complete description of high energy phosphate metabolism after CNS trauma - led to the co-development of the lateral fluid percussion model of rodent TBI - was the first in vivo demonstration that brain trauma was different from ischaemia - identified that energy metabolism differed between brain and spinal cord injury . First to apply proton magnetic resonance spectroscopy (MRS) to the study of TBI and SCI - identified that lactate concentration did not reach injury thresholds after brain trauma - first described that n-acetyl-aspartate was an unsuitable MRS concentration standard after brain injury - first described that n-acetyl-aspartate declined after brain injury . Discovered that brain magnesium concentration declined after TBI - a seminal demonstration that intracellular free magnesium concentration can change in vivo - first to demonstrate that tissue total magnesium can decline after injury - first to calculate the impact of magnesium change on critical bioenergetic parameters in vivo - first to measure altered mitochondrial bioenergetics after TBI . Discovered that magnesium treatment improved outcome after TBI - first description of magnesium as a neuroprotective agent after acute brain injury - first to demonstrate that lowering magnesium concentration was deleterious to outcome - first to demonstrate a dose-response effect for magnesium and define the therapeutic window after TBI . First to apply diffusion weighted imaging to the study of TBI - identified critical early phase of vasogenic oedema following trauma . Discovered that neuropeptides, and in particular substance P, are involved in early oedema formation after TBI and stroke - first to identify neurogenic inflammation as a characteristic feature of acute brain injury - first to describe NK1 antagonists as a novel therapeutic approach to treat oedema - first to describe beneficial effects of combined NK1 antagonists and tPA in stroke - first to describe the efficacy of NK1 antagonists in management of intracranial pressure . Discovered that substance P may play a critical role in cell death in early Parkinson's disease - first to describe NK1 antagonists as a novel therapeutic approach to treat Parkinson's disease . Over 6,500 citations according to Google Scholar . "h" index of 41 . Associate Editor for the journal, Magnesium Research . 0n the editorial boards of Journal of Neurotrauma, Neurotherapeutics and Frontiers in Neurotrauma
Dissertation Note: Thesis (D.Sc.) -- University of Adelaide, School of Molecular and Biomedical Science, 2013
Keywords: magnesium; substance P; nervous; brain injury
Description: Title page, table of contents, dot point summary and list of publications included in thesis only. The complete thesis in print form is available from the University of Adelaide Library.
Appears in Collections:Research Theses

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