Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: Post-translational regulation of sphingosine kinases
Author: Chan, H.
Pitson, S.
Citation: BBA: Molecular and Cell Biology of Lipids, 2013; 1831(1):147-156
Publisher: Elsevier Science BV
Issue Date: 2013
ISSN: 1388-1981
Statement of
Huasheng Chan, Stuart M. Pitson
Abstract: Sphingosine kinases (SKs) catalyse the conversion of sphingosine to sphingosine 1-phosphate (S1P), a signalling lipid that is involved in a plethora of cellular processes including proliferation, apoptosis, calcium homeostasis, angiogenesis, vascular and neuronal maturation, cell migration and immune responses. Over the last few years, it has become clear that SKs are subject to various forms of post-translational regulation which play important roles in the function of these enzymes. Moreover, dysregulation of SKs has been implicated in many pathological conditions, such as cancer. Here we review the various mechanisms of post-translational regulation of the SKs with the view that such knowledge may lead to the development of therapeutic strategies to modulate the activities of these enzymes in the treatment of cancer and a range of other conditions. This article is part of a Special Issue entitled Advances in Lysophospholipid Research.
Keywords: Lipid, Sphingosine kinase, Sphingosine, Sphingosine 1-phosphate, Post-translational regulation, Cancer
Rights: © 2012 Elsevier B.V.
DOI: 10.1016/j.bbalip.2012.07.005
Published version:
Appears in Collections:Aurora harvest 4
Molecular and Biomedical Science publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.