Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/80609
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dc.contributor.authorChan, H.-
dc.contributor.authorPitson, S.-
dc.date.issued2013-
dc.identifier.citationBBA: Molecular and Cell Biology of Lipids, 2013; 1831(1):147-156-
dc.identifier.issn1388-1981-
dc.identifier.issn1879-2618-
dc.identifier.urihttp://hdl.handle.net/2440/80609-
dc.description.abstractSphingosine kinases (SKs) catalyse the conversion of sphingosine to sphingosine 1-phosphate (S1P), a signalling lipid that is involved in a plethora of cellular processes including proliferation, apoptosis, calcium homeostasis, angiogenesis, vascular and neuronal maturation, cell migration and immune responses. Over the last few years, it has become clear that SKs are subject to various forms of post-translational regulation which play important roles in the function of these enzymes. Moreover, dysregulation of SKs has been implicated in many pathological conditions, such as cancer. Here we review the various mechanisms of post-translational regulation of the SKs with the view that such knowledge may lead to the development of therapeutic strategies to modulate the activities of these enzymes in the treatment of cancer and a range of other conditions. This article is part of a Special Issue entitled Advances in Lysophospholipid Research.-
dc.description.statementofresponsibilityHuasheng Chan, Stuart M. Pitson-
dc.language.isoen-
dc.publisherElsevier Science BV-
dc.rights© 2012 Elsevier B.V.-
dc.source.urihttp://dx.doi.org/10.1016/j.bbalip.2012.07.005-
dc.subjectLipid, Sphingosine kinase, Sphingosine, Sphingosine 1-phosphate, Post-translational regulation, Cancer-
dc.titlePost-translational regulation of sphingosine kinases-
dc.typeJournal article-
dc.identifier.doi10.1016/j.bbalip.2012.07.005-
pubs.publication-statusPublished-
dc.identifier.orcidPitson, S. [0000-0002-9527-2740]-
Appears in Collections:Aurora harvest 4
Molecular and Biomedical Science publications

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