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Type: Book chapter
Title: Identification of prostate cancer-associated microRNAs in circulation using a mouse model of disease
Author: Selth, L.
Townley, S.
Gillis, J.
Tilley, W.
Butler, L.
Citation: Circulating MicroRNAs. Methods and Protocols, 2013 / Ochiya, T. (ed./s), pp.235-246
Publisher: Springer
Publisher Place: UK
Issue Date: 2013
ISBN: 9781627034524
Statement of
Luke A. Selth, Scott L. Townley, Joanna L. Gillis, Wayne D. Tilley, and Lisa M. Butler
Abstract: MicroRNAs (miRNAs) derived from the cell-free fractions of blood are emerging as useful noninvasive markers of cancer. However, many tumors display significant molecular heterogeneity, which is likely to be reflected in the circulating miRNA fingerprints associated with that pathology. One strategy to minimize such heterogeneity is to employ genetically engineered mouse models of human cancer. Here, we describe a method to profile miRNAs in the serum of a mouse model of prostate cancer, TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP), and discuss practical considerations for translating these potential biomarkers into a clinical setting.
Keywords: Circulating; microRNA; Mouse model; Plasma; Prostate cancer; Serum; TRAMP
Rights: © Springer Science+Business Media New York 2013
RMID: 0020131329
DOI: 10.1007/978-1-62703-453-1_19
Appears in Collections:Medicine publications

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