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dc.contributor.authorCho, Y.en
dc.contributor.authorBadve, S.en
dc.contributor.authorHawley, C.en
dc.contributor.authorMcDonald, S.en
dc.contributor.authorBrown, F.en
dc.contributor.authorBoudville, N.en
dc.contributor.authorBannister, K.en
dc.contributor.authorClayton, P.en
dc.contributor.authorJohnson, D.en
dc.identifier.citationAmerican Society of Nephrology. Clinical Journal, 2013; 8(9):1556-1563en
dc.description.abstractBACKGROUND AND OBJECTIVES: The effect of biocompatible peritoneal dialysis (PD) solutions on PD-related peritonitis is unclear. This study sought to evaluate the relationship between use of biocompatible solutions and the probability of occurrence or clinical outcomes of peritonitis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The study included all incident Australian patients receiving PD between January 1, 2007, and December 31, 2010, using Australia and New Zealand Dialysis and Transplant Registry data. All multicompartment PD solutions of neutral pH were categorized as biocompatible solutions. The independent predictors of peritonitis and the use of biocompatible solutions were determined by multivariable, multilevel mixed-effects Poisson and logistic regression analysis, respectively. Sensitivity analyses, including propensity score matching, were performed. RESULTS: Use of biocompatible solutions gradually declined (from 7.5% in 2007 to 4.2% in 2010), with preferential use among smaller units and among younger patients without diabetes mellitus. Treatment with biocompatible solution was associated with significantly greater overall rate of peritonitis (0.67 versus 0.47 episode per patient-year; incidence rate ratio, 1.49; 95% confidence interval [CI], 1.19 to 1.89) and with shorter time to first peritonitis (hazard ratio [HR], 1.48; 95% CI, 1.17 to 1.87), a finding replicated in propensity score-matched cohorts (HR, 1.36; 95% CI, 1.09 to 1.71). CONCLUSIONS: In an observational registry study, use of biocompatible PD solutions was associated with higher overall peritonitis rates and shorter time to first peritonitis. Further randomized studies adequately powered for a primary peritonitis outcome are warranted.en
dc.description.statementofresponsibilityYeoungjee Cho, Sunil V. Badve, Carmel M. Hawley, Stephen P. McDonald, Fiona G. Brown, Neil Boudville, Kym M. Bannister, Philip A. Clayton, David W. Johnsonen
dc.publisherAmerican Society of Nephrologyen
dc.rightsCopyright © 2013 by the American Society of Nephrologyen
dc.subjectHumans; Peritonitis; Biocompatible Materials; Dialysis Solutions; Disease-Free Survival; Treatment Outcome; Peritoneal Dialysis; Incidence; Time Factors; Adult; Aged; Middle Aged; Australia; Female; Maleen
dc.titleAssociation of biocompatible peritoneal dialysis solutions with peritonitis risk, treatment, and outcomesen
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidMcDonald, S. [0000-0001-6103-1386]en
dc.identifier.orcidClayton, P. [0000-0001-9190-6753]en
Appears in Collections:Medicine publications

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