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dc.contributor.authorAli, R.-
dc.contributor.authorMeena, S.-
dc.contributor.authorEastwood, B.-
dc.contributor.authorRichards, I.-
dc.contributor.authorMarsden, J.-
dc.identifier.citationDrug and Alcohol Dependence, 2013; 132(1-2):352-361-
dc.description.abstract<h4>Background</h4>The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST 3.0; index test) is a structured interview for alcohol, tobacco, cannabis, stimulants, sedatives and opioid use disorders in general medical settings. Perceived administration time deters routine use. This study releases a short-form: the ASSIST-Lite.<h4>Methods</h4>Diagnostic accuracy study among 2082 adults recruited from general medical (70%) and specialist mental health/addiction treatment services (22%). Current DSM-IV substance dependence (MINI International Neuropsychiatric Interview) and moderate-severe tobacco dependence (Fagerstrom Nicotine Dependence Test) were reference standards. Exploratory factor and item-response theory models re-calibrated ordinal test items. Items for the ASSIST-Lite were selected by diagnostic accuracy evaluation (area under the receiver-operating characteristic [AUC] curve [≤0.7]), sensitivity, specificity, positive and negative predictive values [PVP, NVP], kappa, likelihood ratios [LR+, LR-], and clinical utility index [CU+, CU-]).<h4>Results</h4>For each substance an item pair was selected (AUC [0.8-1.0], sensitivity [0.8-1.0], specificity [0.7-0.8], PVP [0.8-1.0], NVP [0.7-1.0], kappa [0.5-0.9], LR+ [2.5-5.9], LR- [0.0-0.2], CU+ [0.7-0.9], and CU- [0.5-0.8]). Gender, age and recruitment setting (specialist mental health versus general medical) did not moderate accuracy, with the exception of opioids (AUC <0.7, participants ≥59 years). Male opioid users had more severe substance involvement scores that females (differential item functioning analysis, P=0.00). There was no evidence of differential accuracy between countries (AUC range, 0.8-1.0).<h4>Conclusion</h4>The ASSIST-Lite is an ultra-rapid screener which has been optimised for general medical settings. Optionally, a criterion question can be added to capture hazardous drinking, and to capture use of another type of mood-altering substance.-
dc.description.statementofresponsibilityRobert Ali, Sonali Meena, Brian Eastwood, Ian Richards, John Marsden-
dc.publisherElsevier Sci Ireland Ltd-
dc.rightsCrown Copyright © 2013-
dc.subjectAlcohol, Smoking and Substance Involvement Screening Test-
dc.subjectAlcohol, tobacco, cannabis, stimulant, sedative, opioid, substance use disorder-
dc.subjectSubstance dependence-
dc.titleUltra-rapid screening for substance-use disorders: The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST-Lite)-
dc.typeJournal article-
dc.identifier.orcidAli, R. [0000-0003-2905-8153]-
dc.identifier.orcidMarsden, J. [0000-0002-1307-2498]-
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Pharmacology publications

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