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Type: Journal article
Title: Determinants of achieving early blood pressure control with monotherapy in a primary care setting
Author: Stewart, S.
Carrington, M.
Swemmer, C.
Kurstjens, N.
Brown, A.
Burrell, L.
Nelson, M.
Stocks, N.
Jennings, G.
Citation: Journal of Clinical Hypertension, 2013; 15(9):674-680
Publisher: Le Jacq Communications, Inc
Issue Date: 2013
ISSN: 1524-6175
Statement of
Simon Stewart, Melinda J. Carrington, Carla H. Swemmer, Nicol P. Kurstjens, Alex Brown, Louise M. Burrell, Mark Nelson, Nigel P. Stocks, Garry L. Jennings
Abstract: This study sought to identify the determinants of early blood pressure (BP) control associated with monotherapy in hypertensive individuals being managed in the primary care setting. The Valsartan Intensified Primary Care Reduction of Blood Pressure (VIPER-BP) study, was a multicenter, randomized controlled trial of an intensive approach to BP management. During a standardized run-in, 2185 participants commenced monotherapy (valsartan 80 mg/d) for 14 to 28 days. A total of 1978 participants aged 59±12 years (60% men) completed the run-in phase. Of these, 15.1%, 43.5%, and 41.4% participants had an initial BP target of ≤125/75, 130/80, and 140/90 mm Hg, respectively. A total of 416 of 2185 participants (19.0%) subsequently achieved their individual BP target during run-in with a mean BP change of -22.6±12.1/-12.9±8.2 mm Hg vs -4.2±16.2/-3.0±9.6 mm Hg for the rest (P<.001). These early responders were more likely to be women (adjusted odds ratio, 1.41; 95% confidence interval, 1.10-1.80), had lower BP at baseline, were less likely to have been treated previously (or for less time), and had a less stringent BP target. An initial period of monotherapy achieved BP control in a high proportion of hypertensive individuals with key groups (including women and de novo cases) more likely to show an early BP response.
Keywords: VIPER-BP Study Investigators
Antihypertensive Agents
Treatment Outcome
Sex Factors
Blood Pressure
Middle Aged
Primary Health Care
Disease Management
Rights: ©2013 Wiley Periodicals, Inc.
DOI: 10.1111/jch.12164
Appears in Collections:Aurora harvest
General Practice publications

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