Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8125
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Type: Journal article
Title: Maintenance therapy with calcium channel blockers for preventing preterm birth after threatened preterm labour
Author: Gaunekar, N.
Crowther, C.
Citation: The Cochrane Database of Systematic Reviews, 2004; 3(3):www 1-www 24
Publisher: Update Software Ltd
Issue Date: 2004
ISSN: 1469-493X
1465-1858
Statement of
Responsibility: 
Gaunekar NN, Crowther CA
Abstract: <h4>Background</h4>Calcium channel blocker maintenance therapy is one of the types of tocolytic therapy used after an episode of threatened preterm labour (and usually an initial dose of tocolytic therapy) in an attempt to prevent the onset of further preterm contractions.<h4>Objectives</h4>To assess the effects of calcium channel blockers as maintenance therapy on preventing preterm birth after threatened preterm labour.<h4>Search strategy</h4>We searched the Cochrane Pregnancy and Childbirth Group trials register (31 March 2004); MEDLINE (1966 to March 2004) and DARE (June 2003).<h4>Selection criteria</h4>Randomised controlled trials of calcium channel blockers used as maintenance therapy to prevent preterm birth after threatened preterm labour, compared with alternative drug therapy, placebo or no treatment.<h4>Data collection and analysis</h4>Two reviewers independently applied the selection criteria, extracted data from the included study and assessed study quality.<h4>Main results</h4>One trial of 74 women was included. No difference in the incidence of preterm birth was found when calcium channel blocker (nifedipine) maintenance therapy was compared with no treatment. Twenty-five women out of 37 in each group gave birth before 37 weeks (relative risk 1.00, 95% confidence interval 0.73 to 1.37). The trial did not report stillbirths and neonatal deaths prior to discharge. Neurological follow up of the infants was not addressed.<h4>Reviewers' conclusions</h4>The role of maintenance therapy with calcium channel blockers for preventing preterm birth is not clear. Well designed randomised trials of sufficient size with relevant outcomes are required.
Keywords: Humans; Premature Birth; Nifedipine; Calcium Channel Blockers; Pregnancy; Female; Obstetric Labor, Premature
RMID: 0020042211
DOI: 10.1002/14651858.CD004071
Published version: http://mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD004071/frame.html
Appears in Collections:Obstetrics and Gynaecology publications

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