Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8125
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dc.contributor.authorGaunekar, N.en
dc.contributor.authorCrowther, C.en
dc.date.issued2004en
dc.identifier.citationThe Cochrane Database of Systematic Reviews, 2004; 3(3):www 1-www 24en
dc.identifier.issn1469-493Xen
dc.identifier.issn1465-1858en
dc.identifier.urihttp://hdl.handle.net/2440/8125-
dc.description.abstract<h4>Background</h4>Calcium channel blocker maintenance therapy is one of the types of tocolytic therapy used after an episode of threatened preterm labour (and usually an initial dose of tocolytic therapy) in an attempt to prevent the onset of further preterm contractions.<h4>Objectives</h4>To assess the effects of calcium channel blockers as maintenance therapy on preventing preterm birth after threatened preterm labour.<h4>Search strategy</h4>We searched the Cochrane Pregnancy and Childbirth Group trials register (31 March 2004); MEDLINE (1966 to March 2004) and DARE (June 2003).<h4>Selection criteria</h4>Randomised controlled trials of calcium channel blockers used as maintenance therapy to prevent preterm birth after threatened preterm labour, compared with alternative drug therapy, placebo or no treatment.<h4>Data collection and analysis</h4>Two reviewers independently applied the selection criteria, extracted data from the included study and assessed study quality.<h4>Main results</h4>One trial of 74 women was included. No difference in the incidence of preterm birth was found when calcium channel blocker (nifedipine) maintenance therapy was compared with no treatment. Twenty-five women out of 37 in each group gave birth before 37 weeks (relative risk 1.00, 95% confidence interval 0.73 to 1.37). The trial did not report stillbirths and neonatal deaths prior to discharge. Neurological follow up of the infants was not addressed.<h4>Reviewers' conclusions</h4>The role of maintenance therapy with calcium channel blockers for preventing preterm birth is not clear. Well designed randomised trials of sufficient size with relevant outcomes are required.en
dc.description.statementofresponsibilityGaunekar NN, Crowther CAen
dc.language.isoenen
dc.publisherUpdate Software Ltden
dc.source.urihttp://mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD004071/frame.htmlen
dc.subjectHumans; Premature Birth; Nifedipine; Calcium Channel Blockers; Pregnancy; Female; Obstetric Labor, Prematureen
dc.titleMaintenance therapy with calcium channel blockers for preventing preterm birth after threatened preterm labouren
dc.typeJournal articleen
dc.identifier.rmid0020042211en
dc.identifier.doi10.1002/14651858.CD004071en
dc.identifier.pubid55711-
pubs.library.collectionObstetrics and Gynaecology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidCrowther, C. [0000-0002-9079-4451]en
Appears in Collections:Obstetrics and Gynaecology publications

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