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|Title:||BCR-ABL1 kinase domain mutations may persist at very low levels for many years and lead to subsequent TKI resistance|
|Citation:||British Journal of Cancer, 2013; 109(6):1593-1598|
|Publisher:||Nature Publishing Group|
|W T Parker, A L Yeoman, B A Jamison, D T Yeung, H S Scott, T P Hughes, and S Branford|
|Abstract:||<h4>Background</h4>BCR-ABL1 mutation analysis is recommended for chronic myeloid leukaemia patients. However, mutations may become undetectable after changing therapy, and it is unknown whether they have been eradicated.<h4>Methods</h4>We examined longitudinal data of patients with imatinib-resistant mutations, which became undetectable by Sanger sequencing to determine whether mutations could reappear, and the related circumstances.<h4>Results</h4>Identical imatinib- and nilotinib-resistant mutations reappeared following further therapy changes in five patients, and was associated with subsequent nilotinib resistance in four.<h4>Conclusion</h4>The data suggest that some BCR-ABL1 mutations may persist at undetectable levels for many years after changing therapy, and can be reselected and confer resistance to subsequent inhibitors.|
|Keywords:||chronic myeloid leukaemia; mutation analysis; tyrosine kinase inhibitor; resistance|
|Rights:||© 2013 Cancer Research UK. All rights reserved.|
|Appears in Collections:||Medicine publications|
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