Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/81295
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Type: Journal article
Title: Does non-transferrin bound iron contribute to transfusion related immune-modulation in preterms?
Author: Stark, M.
Keir, A.
Andersen, C.
Citation: Archives of Disease in Childhood: Fetal and Neonatal Edition, 2013; 98(5):424-429
Publisher: B M J Publishing Group
Issue Date: 2013
ISSN: 1359-2998
1468-2052
Statement of
Responsibility: 
Michael J Stark, Amy K Keir, Chad C Andersen
Abstract: OBJECTIVE There is increasing awareness that allogeneic transfusion is potentially harmful in preterm neonates secondary to transfusion related immunomodulation (TRIM). Non-transferrin bound iron (NTBI) may contribute to TRIM by promoting oxidative damage and pro-inflammatory cytokine release. The current study aimed to determine if transfusion early in the neonatal period resulted in an increase in circulating NTBI, oxidative stress and immune activation. DESIGN Prospective observational study. SETTING One transfusion event was studied in infants ≤28 weeks gestation between 2 and 6 weeks postnatal age (n=33) admitted to a tertiary neonatal intensive care unit. METHODS Serum NTBI, inflammatory cytokines and malondialdehyde (MDA) were measured from the donor pack, prior to and at 2–4 and 24 h post-transfusion. RESULTS Median (range) age at transfusion was 17 (14–39) days with the pretransfusion haemoglobin level 9.6 (7.4–10.4) g/dl. NTBI was detectable in 18 (51%) of the transfusion packs. NTBI levels were higher after transfusion (p<0.01) returning to pretransfusion levels by 24 h. Post-transfusion NTBI level correlated with the age of transfused blood (p<0.001) and was positively correlated with plasma MDA (p=0.01) but not IL-1β, IL-6, IL8 or TNFα. CONCLUSIONS Circulating NTBI is transiently elevated following blood transfusion in preterm newborns. This increase was related to the age of blood transfused and correlated with increases in oxidative stress but not pro-inflammatory cytokines. While further studies are necessary to determine whether these transient effects influence clinical outcome, the current data do not support a significant role in the very preterm neonate for NTBI in TRIM.
Keywords: Humans
Infant, Premature, Diseases
Iron
Reactive Oxygen Species
Malondialdehyde
Transferrin
Interleukins
Enzyme-Linked Immunosorbent Assay
Erythrocyte Transfusion
Prospective Studies
Oxidative Stress
Infant
Infant, Newborn
Intensive Care Units, Neonatal
Female
Male
Immunomodulation
Infant, Extremely Premature
Rights: Copyright status unknown
DOI: 10.1136/archdischild-2012-303353
Grant ID: http://purl.org/au-research/grants/nhmrc/565512
Appears in Collections:Aurora harvest
Medical Sciences publications

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