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Type: Journal article
Title: Acute effects of oral preloads with increasing energy density on gastric emptying, gut hormone release, thermogenesis and energy intake, in overweight and obese men
Author: Luscombe-Marsh, N.
Seimon, R.
Bollmeyer, E.
Wishart, J.
Wittert, G.
Horowitz, M.
Bellon, M.
Feinle-Bisset, C.
Citation: Asia Pacific Journal of Clinical Nutrition, 2013; 22(3):380-390
Publisher: H E C Press
Issue Date: 2013
ISSN: 0964-7058
Statement of
Natalie D Luscombe-Marsh ; Radhika V Seimon ; Erin Bollmeyer ; Judith M Wishart ; Gary A Wittert ; Michael Horowitz ; Max Bellon ; Christine Feinle-Bisset
Abstract: This study investigated the effect of high-and low-energy density preloads on gastrointestinal and metabolic factors, which act to regulate acute energy intake. Sixteen overweight and obese men (BMI range: 27.2-36.5 kg/m^2) each received 3 oral preloads in randomised order: i) high-energy-density, high-fat (1.5 kcal/g), ii) low-energydensity, high-fat (1.1 kcal/g), and iii) low-energy-density, high-protein (1.1 kcal/g). Over 180 min, gastric emptying, plasma glucagon-like peptide-1 concentrations, and diet-induced thermogenesis were assessed, and subsequent energy intake was determined. Total energy intake did not differ between preloads (high-energy-density, high-fat, 2059±72 kilocalories (kcal); low-energy-density, high-fat, 1876±91 kcal; and low-energy-density, highprotein, 1867±63 kcal). Gastric emptying was slower following the high-energy-density, high-fat preload (158±8 min) compared with the low-energy-density, high-protein preload (130±9 min) (p=0.05), but did not differ between the high-energy-density, high-fat and low-energy-density, high-fat (147±8 min) preloads. Plasma glucagon-like peptide-1 did not differ substantially between preloads. Diet-induced thermogenesis was lower following high-energy-density, high-fat (10.4±0.7 %) than low-energy-density, high-fat (14.9±1.2 %) and low-energydensity, high-protein (18.1±1.1 %) preloads (p<0.01 for both). We conclude that an increased energy density slows gastric emptying and reduces thermogenesis, but that a high fat content overrides the effect of energy density on gastric emptying. The counter-regulatory modulation of these gastric and metabolic factors may explain, at least in part, the lack of differences in subsequent energy intake in response to oral preloads with increasing energy density.
Keywords: 腸道功能; 體重調節; 高脂飲食; 高蛋白飲食; 人類; gut function; body weight regulation; high-fat diet; high-protein diet; humans
Rights: Copyright status unknown
RMID: 0020131777
DOI: 10.6133/apjcn.2013.22.3.11
Appears in Collections:Medicine publications

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