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dc.contributor.authorFuchs, T.-
dc.contributor.authorTrollor, J.-
dc.contributor.authorCrawford, J.-
dc.contributor.authorBrown, D.-
dc.contributor.authorBaune, B.-
dc.contributor.authorSamaras, K.-
dc.contributor.authorCampbell, L.-
dc.contributor.authorBreit, S.-
dc.contributor.authorBrodaty, H.-
dc.contributor.authorSachdev, P.-
dc.contributor.authorSmith, E.-
dc.identifier.citationAging Cell, 2013; 12(5):882-889-
dc.description.abstractHigher levels of macrophage inhibitory cytokine-1, also known as growth differentiation factor 15 (MIC-1/GDF15), are associated with adverse health outcomes and all-cause mortality. The aim of this study was to examine the relationships between MIC-1/GDF15 serum levels and global cognition, five cognitive domains, and mild cognitive impairment (MCI), at baseline (Wave 1) and prospectively at 2 years (Wave 2), in nondemented participants aged 70-90 years. Analyses were controlled for age, sex, education, Framingham risk score, history of cerebrovascular accident, acute myocardial infarction, angina, cancer, depression, C-reactive protein, tumor necrosis factor-α, interleukins 6 and 12, and apolipoprotein ε4 genotype. Higher MIC-1/GDF15 levels were significantly associated with lower global cognition at both waves. Cross-sectional associations were found between MIC-1/GDF15 and all cognitive domains in Wave 1 (all P < 0.001) and between processing speed, memory, and executive function in Wave 2 (all P < 0.001). Only a trend was found for the prospective analyses, individuals with high MIC-1/GDF15 at baseline declined in global cognition, executive function, memory, and processing speed. However, when categorizing MIC-1/GDF15 by tertiles, prospective analyses revealed statistically significant lower memory and executive function in Wave 2 in those in the upper tertile compared with the lower tertile. Receiver operating characteristics (ROC) analysis was used to determine MIC-1/GDF15 cutoff values associated with cognitive decline and showed that a MIC-1/GDF15 level exceeding 2764 pg/ml was associated with a 20% chance of decline from normal to MCI or dementia. In summary, MIC-1/GDF15 levels are associated with cognitive performance and cognitive decline. Further research is required to determine the pathophysiology of this relationship.-
dc.description.statementofresponsibilityTalia Fuchs, Julian N. Trollor, John Crawford, David A. Brown, Bernhard T. Baune, Katherine Samaras, Lesley Campbell, Samuel N. Breit, Henry Brodaty, Perminder Sachdev, and Evelyn Smith-
dc.publisherWiley-Blackwell Publishing Ltd-
dc.rights© 2013 The Anatomical Society and John Wiley & Sons Ltd-
dc.subjectcognitive decline-
dc.subjectgrowth differentiation factor-15-
dc.subjectmacrophage inhibitory cytokine-1-
dc.subjectmild cognitive impairment-
dc.titleMacrophage inhibitory cytokine-1 is associated with cognitive impairment and predicts cognitive decline - the Sydney memory and aging study-
dc.typeJournal article-
dc.identifier.orcidBaune, B. [0000-0001-6548-426X]-
Appears in Collections:Aurora harvest 4
Psychiatry publications

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