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https://hdl.handle.net/2440/81470
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dc.contributor.author | Mrozik, K. | - |
dc.contributor.author | Wada, N. | - |
dc.contributor.author | Marino, V. | - |
dc.contributor.author | Richter, W. | - |
dc.contributor.author | Shi, S. | - |
dc.contributor.author | Wheeler, D. | - |
dc.contributor.author | Gronthos, S. | - |
dc.contributor.author | Bartold, P. | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Regenerative Medicine, 2013; 8(6):711-723 | - |
dc.identifier.issn | 1746-0751 | - |
dc.identifier.issn | 1746-076X | - |
dc.identifier.uri | http://hdl.handle.net/2440/81470 | - |
dc.description.abstract | Aim: To investigate the capacity of allogeneic periodontal ligament stem cells (PDLSCs) to regenerate periodontal tissues using an ovine periodontal defect model. Materials & methods: Surgically created zero-wall dehiscence periodontal defects created in Merino sheep were filled with 1 × 107 allogeneic PDLSCs attached to Gelfoam®, Gelfoam alone or left untreated. After 4 weeks, histological analysis was performed to assess periodontal regeneration. Results: Allogeneic PDLSCs were well tolerated by recipient animals. The mean area of new alveolar bone was significantly greater in the PDLSC + Gelfoam treatment group compared with the defect-alone group. The PDLSC + Gelfoam and Gelfoam-only treatment groups displayed significantly greater length of new cementum and percentage of cementum regrowth compared with the defect-alone group. New Sharpey‘s fibers were generally more organized and significantly thicker within the PDLSC + Gelfoam treatment group. The PDLSC + Gelfoam treatment group also showed a trend of increased Sharpey‘s fiber attachment length compared with the Gelfoam-only and defect-alone groups. Conclusion: These studies support the potential use of allogeneic PDLSC preparations as viable therapies for periodontal regeneration in the clinical setting. | - |
dc.description.statementofresponsibility | Krzysztof Marek Mrozik, Naohisa Wada, Victor Marino, Ward Richter, Songtao Shi, Donna L Wheeler, Stan Gronthos, and P Mark Bartold | - |
dc.language.iso | en | - |
dc.publisher | Future Medicine Ltd | - |
dc.rights | © Future Medicine | - |
dc.source.uri | http://dx.doi.org/10.2217/rme.13.66 | - |
dc.subject | allogeneic | - |
dc.subject | alveolar bone | - |
dc.subject | cementum | - |
dc.subject | periodontal ligament stem cells | - |
dc.subject | regeneration | - |
dc.subject | Sharpey‘s fibers | - |
dc.title | Regeneration of periodontal tissues using allogeneic periodontal ligament stem cells in an ovine model | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.2217/rme.13.66 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/299009 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/453599 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Mrozik, K. [0000-0002-4890-8208] | - |
dc.identifier.orcid | Gronthos, S. [0000-0002-6225-3084] | - |
dc.identifier.orcid | Bartold, P. [0000-0002-5695-3877] | - |
Appears in Collections: | Aurora harvest 4 Dentistry publications |
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