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https://hdl.handle.net/2440/81690
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Type: | Journal article |
Title: | Emu oil expedites small intestinal repair following 5-fluorouracil-induced mucositis in rats |
Author: | Mashtoub, S. Tran, C. Howarth, G. |
Citation: | Experimental Biology and Medicine, 2013; 238(11):1305-1317 |
Publisher: | Blackwell Science Inc |
Issue Date: | 2013 |
ISSN: | 1535-3702 1535-3699 |
Statement of Responsibility: | Suzanne Mashtoub, Cuong D Tran and Gordon S Howarth |
Abstract: | Mucositis resulting from cancer chemotherapy is characterized by intestinal inflammation and ulceration. Previously, emu oil (EO) improved intestinal architecture (Br J Nutr, 2010) in a rat model of chemotherapy-induced mucositis. We investigated EO for its further potential to promote intestinal repair in this mucositis model. Female Dark Agouti rats (n = 8/group) were gavaged with water, olive oil (OO) or EO once daily (1 mL), injected with 5-fluorouracil (5-FU) or saline on day 5 and euthanized on day 8, 9, 10 or 11. Intestinal villus height (VH) and crypt depth (CD), neutral mucin-secreting goblet cell (GC) count, myeloperoxidase (MPO) activity and selected cytokines were quantified; P < 0.05 was considered significant. In 5-FU-injected rats, only EO administration significantly increased VH in the ileum (day 8), jejunum and jejunum–ileum junction (days 8 and 9) compared to 5-FU controls (P < 0.05). GC count was significantly reduced by 5-FU (jejunum: days 8 and 9; ileum: day 8; P < 0.05) and EO increased ileal GC on days 10 and 11 compared to 5-FU controls. MPO activity was significantly increased in jejunum (days 8 and 9) and ileum (day 8) following 5-FU injection, compared to normal controls (P < 0.05). Both EO and OO significantly reduced jejunal MPO on days 8 and 9; however, only EO decreased ileal MPO on day 8. Cytokine levels were not significantly affected by either oil or 5-FU administration at the day 8 time point. Promotion of repair from injury could represent a new mechanism of action for EO, suggesting potential as an adjunct to conventional treatment approaches for cancer management. |
Keywords: | Chemotherapy intestinal mucositis emu oil repair rat |
Rights: | © 2013 by the Society for Experimental Biology and Medicine |
DOI: | 10.1177/1535370213493718 |
Published version: | http://dx.doi.org/10.1177/1535370213493718 |
Appears in Collections: | Aurora harvest Physiology publications |
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