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|Title:||Leptin alters the structural and functional characteristics of adipose tissue before birth|
|Citation:||FASEB Journal, 2003; 17(6):www 1-www 22|
|Publisher:||Federation Amer Soc Exp Biol|
|B. S. J. Yuen, P. C. Owens, B. S. Muhlhausler, C. T. Roberts, M. E. Symonds, D. H. Keisler, J. R. McFarlane, K. G. Kauter, Y. Evens, and I. C. McMillen|
|Abstract:||This study aimed to determine for the first time whether leptin can act to alter the structural and functional characteristics of adipose tissue before birth. Leptin (0.48 mg/kg/day) or saline was infused intravenously into fetal sheep for 4 days from either 136 or 137 days of gestation (term=147±3 days). Circulating leptin concentrations were increased approximately four- to fivefold by leptin infusion. Leptin infusion resulted in a significant increase in the proportion of smaller lipid locules present within fetal perirenal adipose tissue (PAT), and this was associated with a significant increase in the proportion of multilocular tissue and a significant decrease in the proportion and relative mass of unilocular tissue in fetal PAT. The relative abundance of leptin mRNA in fetal PAT was significantly lower in the leptin-infused group, and there was a positive correlation between the relative abundance of leptin mRNA and the proportion of unilocular adipose tissue in fetal PAT. The amount of uncoupling protein 1 tended to be higher (P=0.06) in leptin-infused compared with saline-infused fetuses. This is the first demonstration that leptin can act to regulate the lipid storage characteristics, leptin synthetic capacity, and potential thermogenic functions of fat before birth.|
|Keywords:||fetus; lipid; UCP1|
|Rights:||© Federation of American Societies for Experimental Biology|
|Appears in Collections:||Obstetrics and Gynaecology publications|
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