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dc.contributor.authorDonnelley, M.-
dc.contributor.authorMorgan, K.-
dc.contributor.authorSiu, K.-
dc.contributor.authorFarrow, N.-
dc.contributor.authorStahr, C.-
dc.contributor.authorBoucher, R.-
dc.contributor.authorFouras, A.-
dc.contributor.authorParsons, D.-
dc.identifier.citationScientific Reports, 2014; 4(3689):1-7-
dc.description.abstractTo determine the efficacy of potential cystic fibrosis (CF) therapies we have developed a novel mucociliary transit (MCT) measurement that uses synchrotron phase contrast X-ray imaging (PCXI) to non-invasively measure the transit rate of individual micron-sized particles deposited into the airways of live mice. The aim of this study was to image changes in MCT produced by a rehydrating treatment based on hypertonic saline (HS), a current CF clinical treatment. Live mice received HS containing a long acting epithelial sodium channel blocker (P308); isotonic saline; or no treatment, using a nebuliser integrated within a small-animal ventilator circuit. Marker particle motion was tracked for 20 minutes using PCXI. There were statistically significant increases in MCT in the isotonic and HS-P308 groups. The ability to quantify in vivo changes in MCT may have utility in pre-clinical research studies designed to bring new genetic and pharmaceutical treatments for respiratory diseases into clinical trials.-
dc.description.statementofresponsibilityMartin Donnelley, Kaye S. Morgan, Karen K. W. Siu, Nigel R. Farrow, Charlene S. Stahr, Richard C. Boucher, Andreas Fouras & David W. Parsons-
dc.publisherNature Publishing Group-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit © The Authors-
dc.subjectBiomedical engineering-
dc.subjectPre-clinical studies-
dc.titleNon-invasive airway health assessment: Synchrotron imaging reveals effects of rehydrating treatments on mucociliary transit in-vivo-
dc.typeJournal article-
dc.identifier.orcidDonnelley, M. [0000-0002-5320-7756]-
dc.identifier.orcidFarrow, N. [0000-0002-2289-1268]-
dc.identifier.orcidParsons, D. [0000-0003-1746-3290]-
Appears in Collections:Aurora harvest 4
Paediatrics publications

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