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Type: Journal article
Title: Antisense transcription of a murine FGFR-3 pseudogene during fetal development
Author: Weil, D.
Power, M.
Webb, G. C.
Li, C. L.
Citation: Gene. 187:115-122
Issue Date: 1997
ISSN: 0378-1119
Statement of
Dominique Weil, Mary-Anne Power, Graham C Webb, Chung Leung Li
Abstract: In a search for new protein tyrosine kinases (PTKs) in early hemopoietic cells, we have identified a sequence closely related to the Fibroblast Growth Factor Receptor (FGFR) family. A cDNA isolated from a mouse embryo library was 89% identical to FGFR-3 in both its coding and 3′ untranslated regions. However, the region homologous to exons 5 to 9 of FGFR-3 was missing. In addition, the ORF was interrupted by several stop codons and frame shifts, indicating that this sequence is not functional. These transcripts were therefore copied from a novel FGFR-3 pseudogene, that we called ψFGFR-3. Partial analysis of this gene showed the absence of introns, which is a characteristic feature of a processed pseudogene. ψFGFR-3 gene was localized on Chromosome 1H4-6. Its transcription was shown to be antisense and its expression was restricted to fetal tissues. These results indicate that ψFGFR-3 has been inserted in Chromosome 1 in antisense orientation close to a heterologous promoter.
Keywords: Tyrosine kinase; Cloning; Inactivation; Processed pseudogene; Chromosomal localization; Alternative splicing
DOI: 10.1016/S0378-1119(96)00733-0
Appears in Collections:Obstetrics and Gynaecology publications

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