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|Title:||Clinical utility of EUS before cholangioscopy in the evaluation of difficult iliary strictures|
|Citation:||Gastrointestinal Endoscopy, 2013; 78(6):868-874|
|Nam Q. Nguyen, Mark N. Schoeman, Andrew Ruszkiewicz|
|Abstract:||<h4>Background</h4>Biliary tract malignancies can be assessed with either EUS or SpyGlass cholangioscopy (SGC).<h4>Objective</h4>To evaluate the impact of EUS and guided biopsy before considering SGC in patients who had biliary strictures with negative ductal brushing.<h4>Design</h4>Prospective, observational study.<h4>Setting</h4>Tertiary level referral hospital.<h4>Patients</h4>Forty consecutive patients with biliary strictures.<h4>Intervention</h4>EUS evaluation and biopsy, where possible, were performed in all patients. If EUS examination failed to provide a definitive diagnosis, SGC and ductal biopsy was performed. Results were compared with surgical specimens or positive histocytology.<h4>Main outcome measurements</h4>Tissue diagnosis, technical success, adverse events, and clinical outcomes.<h4>Results</h4>On EUS, abnormalities responsible for the biliary strictures were identified in 39 patients (98%), with FNA achievable in 30 patients (75%). EUS-FNA provided positive histocytology in 23 patients (58%). SGC-guided biopsy was performed to evaluate nondiagnostic EUS-FNA (17 patients) and to clarify autoimmune pancreatitis on FNA (2 patients). The procedure was successful in 18 patients (95%) and provided tissue diagnosis in 16 patients (88%), with 2 false-negative results from extrinsic pathologies. When EUS was used before the SGC approach, the need for SGC was avoided in 24 patients (60%), cholangitis was minimized in 2.5%, and a cost saving of U.S.$110,000 was realized. Tissue diagnosis was achieved in 38 patients (94%) with this approach.<h4>Limitations</h4>Relatively small sample size.<h4>Conclusions</h4>EUS evaluation in patients with difficult biliary stricture prevents the need, cost, and adverse events of SGC in 60% of patients. Together, EUS followed by the SGC approach provides correct clinical diagnosis in 94% of patients with minimal adverse events.|
|Keywords:||Bile Ducts, Intrahepatic; Humans; Cholangiocarcinoma; Bile Duct Neoplasms; Gallbladder Neoplasms; Pancreatic Neoplasms; Cholangitis, Sclerosing; Pancreatitis; Autoimmune Diseases; Constriction, Pathologic; Jaundice, Obstructive; Endosonography; Endoscopy, Digestive System; Prospective Studies; Middle Aged; Female; Male; Endoscopic Ultrasound-Guided Fine Needle Aspiration|
|Rights:||Copyright © 2013 American Society for Gastrointestinal Endoscopy|
|Appears in Collections:||Medicine publications|
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