Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/81891
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Type: Journal article
Title: Advances in understanding the pathogenesis of autoimmune disorders: focus on chemokines and lymphocyte trafficking
Author: Comerford, I.
Kara, E.
McKenzie, D.
McColl, S.
Citation: British Journal of Haematology, 2013; 164(3):329-341
Publisher: Blackwell Publishing Ltd
Issue Date: 2013
ISSN: 0007-1048
1365-2141
Statement of
Responsibility: 
Iain Comerford, Ervin E. Kara, Duncan R. McKenzie and Shaun R. McColl
Abstract: Lymphocyte trafficking is a key step in the pathogenesis of various autoimmune diseases. Recruitment of autoreactive lymphocytes to inflamed tissues is a defining feature of numerous persistent organ-specific autoimmune conditions and various therapies are now used in several of these diseases which appear to specifically block lymphocyte migration. Thus, better understanding of the molecular events involved in homing of autoreactive pathogenic lymphocytes may present novel opportunities for pharmacological intervention in autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, type-1 diabetes and psoriasis. This review describes recent progress in understanding lymphocyte trafficking in autoimmunity, focusing on the involvement of the chemokine and chemokine receptor superfamily. Possible strategies to improve therapeutics for autoimmune diseases arising from these studies are discussed.
Keywords: chemokines; autoimmunity; lymphocytes; T cells; cell migration
Rights: © 2013 John Wiley & Sons Ltd.
RMID: 0020133960
DOI: 10.1111/bjh.12616
Appears in Collections:Molecular and Biomedical Science publications

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