Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Advances in understanding the pathogenesis of autoimmune disorders: focus on chemokines and lymphocyte trafficking|
|Citation:||British Journal of Haematology, 2013; 164(3):329-341|
|Publisher:||Blackwell Publishing Ltd|
|Iain Comerford, Ervin E. Kara, Duncan R. McKenzie and Shaun R. McColl|
|Abstract:||Lymphocyte trafficking is a key step in the pathogenesis of various autoimmune diseases. Recruitment of autoreactive lymphocytes to inflamed tissues is a defining feature of numerous persistent organ-specific autoimmune conditions and various therapies are now used in several of these diseases which appear to specifically block lymphocyte migration. Thus, better understanding of the molecular events involved in homing of autoreactive pathogenic lymphocytes may present novel opportunities for pharmacological intervention in autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, type-1 diabetes and psoriasis. This review describes recent progress in understanding lymphocyte trafficking in autoimmunity, focusing on the involvement of the chemokine and chemokine receptor superfamily. Possible strategies to improve therapeutics for autoimmune diseases arising from these studies are discussed.|
|Keywords:||chemokines; autoimmunity; lymphocytes; T cells; cell migration|
|Rights:||© 2013 John Wiley & Sons Ltd.|
|Appears in Collections:||Molecular and Biomedical Science publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.