Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/81925
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Type: Journal article
Title: The effect of peri-conception hyperglycaemia and the involvement of the hexosamine biosynthesis pathway in mediating oocyte and embryo developmental competence
Author: Frank, L.
Sutton-McDowall, M.
Gilchrist, R.
Thompson, J.
Citation: Molecular Reproduction and Development, 2014; 81(5):391-408
Publisher: John Wiley
Issue Date: 2014
ISSN: 1098-2795
1098-2795
Organisation: Robinson Institute
Statement of
Responsibility: 
Laura A. Frank, Melanie L. Sutton-McDowall, Robert B. Gilchrist, and Jeremy G. Thompson
Abstract: The environment that the oocyte is exposed to during the peri-conception period can have a significant impact on oocyte developmental competence (the ability of the oocyte to support fertilisation and subsequent embryo development) and the long-term health of the resulting offspring. This is particularly true for maternal hyperglycaemia. While maternal hyperglycaemia during early pregnancy through term development has been extensively studied, the effects on the oocyte itself, and the underlying mechanisms, remain largely unknown. There is increasing evidence, however, for the role of the fuel-sensing hexosamine biosynthesis pathway in mediating the effects of hyperglycaemia in many different cell types. In this review, we will focus on the reproductive consequences of maternal hyperglycaemia during the peri-conceptual period and the role of the hexosamine pathway in mediating these processes.
Keywords: Oocytes; Animals; Humans; Hyperglycemia; Hexosamines; Embryonic Development; Pregnancy; Female; Embryo, Mammalian
Rights: © 2014 Wiley Periodicals, Inc.
RMID: 0030000188
DOI: 10.1002/mrd.22299
Appears in Collections:Obstetrics and Gynaecology publications

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