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|Title:||Chronic deciduitis in the placental basal plate: definition and interobserver reliability|
|Citation:||Human Pathology, 2000; 31(3):292-295|
|Publisher:||W B Saunders Co|
|Yee Khong, T.; Bendon, Robert W.; Qureshi, Faisal; Redline, Raymond W.; Gould, Stephen; Stallmach, Thomas; Lipsett, Jill; Staples, Alan|
|Abstract:||This study tested whether concordance could be achieved for abnormal inflammation in the basal decidua of placental specimens among 6 pathologists experienced in placental pathology. Thirty microscope slides were evaluated by the pathologists for chronic deciduitis. They also scored the severity and extent of inflammation and the presence of plasma cells. No definition of chronic deciduitis was provided. Concordance (5/6 or 6/6 agreement) was achieved in 23 cases (76%). Spearman's rank correlation showed that the diagnosis of chronic deciduitis was almost identical to the assessment of the severity of the inflammation. A regression analysis showed that the perception of severity (and hence chronic deciduitis) was influenced by the other 2 variables, extent and plasma cells. The results were shared with the pathologists, and 25 cases (excluding those with previous 6/6 consensus) were reevaluated. Concordance was now achieved in the 83% of those remaining cases. Using a threshold based on the severity and the extent of lymphocytes, and the presence of plasma cells, pathologists are able to diagnose chronic deciduitis with sufficient concordance to be of value in clinical correlation studies.|
|Keywords:||Decidua; Plasma Cells; Humans; Chorioamnionitis; Chronic Disease; Observer Variation; Regression Analysis; Reproducibility of Results; Pregnancy; Adult; Female|
|Appears in Collections:||Obstetrics and Gynaecology publications|
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