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Type: Book chapter
Title: Improving the neurodevelopmental outcomes of low-birthweight infants
Author: Makrides, M.
Anderson, A.
Gibson, R.
Collins, C.
Citation: Maternal and Child Nutrition: The First 1,000 Days, 2013 / Bhatia, J., Bhutta, Z., Kalhan, S. (ed./s), vol.74, pp.211-221
Publisher: S Karger AG
Issue Date: 2013
Series/Report no.: Nestlé Nutrition Institute Workshop; 74
ISBN: 9783318023879
Editor: Bhatia, J.
Bhutta, Z.
Kalhan, S.
Statement of
Makrides M., Anderson A., Gibson R.A., Collins C.T.
Abstract: Infants born with low birthweight (LBW) have poorer neurodevelopmental outcomes compared with their term counterparts with appropriate weight for gestational age. The perinatal period is a time of high energy and high nutrient needs, and any process, such as preterm birth, poor nutrition or placental insufficiency, that interrupts the concentrated flow of nutrients to the fetus may result in babies with LBW. Therefore, it makes logical sense that at least part of the cognitive deficits may be explained by nutritional deprivation. The nutrients commonly deficient in LBW infants include protein and energy and micronutrients such as iron, zinc and long chain polyunsaturated fatty acids. In this review, we aimed to determine the effect of nutrient supplementation on neurodevelopment in LBW infants. While few trials have supported the hypothesis that nutritional supplementation improves neurodevelopment, many studies are limited by sample size and methodological shortcomings. Further large-scale rigorously designed intervention trials, with long-term neurodevelopment follow-up, are required to determine the optimal nutritional supplements and the timing of their administration to LBW infants.
Keywords: Nervous System
Fetal Growth Retardation
Deficiency Diseases
Protein-Energy Malnutrition
Cognition Disorders
Nutritional Requirements
Dietary Supplements
Infant, Newborn
Infant, Low Birth Weight
Infant, Premature
Infant Nutritional Physiological Phenomena
Rights: © 2013 Nestec Ltd., Vevey/S. Karger AG, Basel
DOI: 10.1159/000348775
Appears in Collections:Aurora harvest
Paediatrics publications

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