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Type: Journal article
Title: Sleep apnea cardiovascular clinical trials-current status and steps forward: the International Collaboration of Sleep Apnea Cardiovascular Trialists
Author: Gottlieb, D.
Craig, S.
Lorenzi-Filho, G.
Heeley, E.
Redline, S.
McEvoy, R.
Duran-Cantolla, J.
Citation: Sleep, 2013; 36(7):975-980
Publisher: Amer Academy Sleep Medicine
Issue Date: 2013
ISSN: 0161-8105
Statement of
Daniel J. Gottlieb, Sonya E. Craig, Geraldo Lorenzi-Filho, Emma Heeley, Susan Redline, R. Doug McEvoy and Joaquín Durán-Cantolla
Abstract: Sleep apnea is a common chronic disease that is associated with coronary heart disease, stroke, heart failure and mortality, although the ability of sleep apnea treatment to reduce cardiovascular morbidity and mortality has not been demonstrated. In contrast to patients seeking treatment in sleep disorders centers, as many as half of individuals with moderate to severe sleep apnea in the general population do not report excessive sleepiness; however, if treatment of sleep apnea were shown to reduce cardiovascular disease risk, this would provide a strong rationale for treatment of sleep apnea even in the absence of daytime sleepiness. This article summarizes the status of clinical trials evaluating the potential cardiovascular benefits of sleep apnea treatment and discusses the challenges of conducting such trials, and introduces the International Collaboration of Sleep Apnea Cardiovascular Trialists (INCOSACT), a clinical research collaboration formed to foster cardiovascular sleep research.
Keywords: cardiovascular disease
clinical trials
sleep apnea
Rights: Copyright status unknown
DOI: 10.5665/sleep.2790
Appears in Collections:Aurora harvest
Medical Sciences publications

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