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Type: Journal article
Title: Predictors of long-Term adherence to Continuous Positive Airway Pressure Therapy in Patients with obstructive sleep apnea and cardiovascular disease in the SAVE Study
Author: Chai-Coetzer, C.
Luo, Y.
Antic, N.
Xi-Long, Z.
Chen, B.
He, Q.
Heeley, E.
Huang, S.
Anderson, C.
Zhong, N.
McEvoy, R.
Citation: Sleep, 2013; 36(12):1929-1937
Publisher: Amer Academy Sleep Medicine
Issue Date: 2013
ISSN: 0161-8105
Statement of
Ching Li Chai-Coetzer, Yuan-Ming Luo, Nick A. Antic, Xi-Long Zhang, Bao-Yuan Chen, Quan-Ying He, Emma Heeley, Shao-Guang Huang, Craig Anderson, Nan-Shan Zhong and Doug McEvoy
Abstract: STUDY OBJECTIVES: To determine the clinical variables that best predict long- term continuous positive airway pressure (CPAP) adherence among patients with cardiovascular disease who have obstructive sleep apnea (OSA). DESIGN: 12-mo prospective within-trial observational study. SETTING: Centers in China, Australia, and New Zealand participating in the Sleep Apnea cardioVascular Endpoints (SAVE) study. PATIENTS: There were 275 patients age 45-70 y with cardiovascular disease (i.e., previously documented transient ischemic attack, stroke, or coronary artery disease) and OSA (4% oxygen desaturation index (ODI) > 12) who were randomized into the CPAP arm of the SAVE trial prior to July 1, 2010. METHODS: Age, sex, country of residence, type of cardiovascular disease, baseline ODI, severity of sleepiness, and Hospital Anxiety and Depression Scale (HADS) scores plus CPAP side effects and adherence at 1 mo were entered in univariate analyses in an attempt to identify factors predictive of CPAP adherence at 12 mo. Variables with P < 0.2 were then included in a multivariate analysis using a linear mixed model with sites as a random effect and 12-mo CPAP use as the dependent outcome variable. MEASUREMENTS AND RESULTS: CPAP adherence at 1, 6, and 12 mo was (mean ± standard deviation) 4.4 ± 2.0, 3.8 ± 2.3, and 3.3 ± 2.4 h/night, respectively. CPAP use at 1 mo (effect estimate ± standard error, 0.65 ± 0.07 per h increase, P < 0.001) and side effects at 1 mo (-0.24 ± 0.092 per additional side effect, P = 0.009) were the only independent predictors of 12- mo CPAP adherence. CONCLUSION: Continuous positive airway pressure use in patients with coexisting cardiovascular disease and moderate to severe obstructive sleep apnea decreases significantly over 12 months. This decline can be predicted by early patient experiences with continuous positive airway pressure (i.e., adherence and side effects at 1 month), raising the possibility that intensive early interventions could improve long-term continuous positive airway pressure compliance in this patient population.
Keywords: Cardiovascular disease; compliance; continuous positive airway pressure; obstructive sleep apnea
Rights: Copyright status unknown
RMID: 0020135379
DOI: 10.5665/sleep.3232
Appears in Collections:Medical Sciences publications

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