Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/82323
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Type: Journal article
Title: A randomized double-blind clinical trial of a continuous 96-hour levobupivacaine infltration after open or laparoscopic colorectal surgery for postoperative pain management - including clinically important changes in protein binding
Author: Krishnan, S.
Morris, R.
Hewett, P.
Field, J.
Karatassas, A.
Tou, S.
Westley, I.
Wicks, F.
Tonkin, J.
Citation: Therapeutic Drug Monitoring, 2014; 36(2):202-210
Publisher: Lippincott Williams & Wilkins
Issue Date: 2014
ISSN: 0163-4356
1536-3694
Statement of
Responsibility: 
Sumithra Krishnan, Raymond G. Morris, Peter J. Hewett, John Field, Alex Karatassas, Samson Tou, Ian S. Westley, Fiona A.Wicks and Julie A. Tonkin
Abstract: Background: Continuous local anesthetic infiltration has been used for pain management after open colorectal surgery. However, its application to patients undergoing laparoscopic colorectal surgery has not been examined. The aim of this prospective, randomized, double-blind, placebo-controlled clinical trial was to study the use of a commercial infiltration device in patients undergoing open or laparoscopic colorectal surgery, along with plasma concentrations of levobupivacaine, its acute-phase binding protein (alpha-1 acid glycoprotein, AAG), and the stress marker, cortisol. Methods: Eligible patients were randomized (2:1) to receive a continuous infiltration of either levobupivacaine or placebo using a commercial device (ON-Q PainBuster) inserted in the preperitoneal layer at the end of surgery. Blood was sampled for determination of levobupivacaine and AAG and cortisol concentrations. Other outcomes measured were pain scores, morbidity and mortality, time to bowel movement, mobilization, and length of hospitalization. Results: In patients having open surgery, the levobupivacaine treatment showed a trend toward reduced total opioid consumption. No patients reported adverse effects attributable to levobupivacaine, despite 11 patients having concentrations at some time(s) during the 96-hour infiltration of up to 5.5 mg/L exceeding a putative toxicity threshold of 2.7 mg/L. AAG concentrations measured postsurgery increased by a mean of 55% (P < 0.001) at 48 hours. Cortisol concentrations also increased significantly by a mean of 191% at 1 hour. Conclusions: Continuous local anesthetic infiltration may be more beneficial in open surgery. The threshold for adverse effects from highly bound local anesthetic drugs established in healthy volunteers is of limited usefulness in clinical scenarios in which AAG concentration increases in response to surgical stress. Hence, there is scope to adopt higher doses to enhance therapeutic benefit.
Keywords: Local anesthetic; levobupivacaine; laparoscopic surgery; pain management; protein binding; alpha-1 acid glycoprotein
Rights: © 2014 by Lippincott Williams & Wilkins
RMID: 0020135415
DOI: 10.1097/FTD.0b013e3182a3772e
Appears in Collections:Surgery publications

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