Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/82366
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Surgical margins and risk of locoregional recurrence in invasive breast cancer: An analysis of 10-year data from the Breast Cancer Treatment Quality Assurance Project
Author: Behm, E.
Beckmann, K.
Dahlstrom, J.
Zhang, Y.
Cho, C.
Stuart-Harris, R.
Craft, P.
Rezo, A.
Buckingham, J.
Citation: The Breast, 2013; 22(5):839-844
Publisher: Churchill Livingstone
Issue Date: 2013
ISSN: 0960-9776
1532-3080
Statement of
Responsibility: 
Eirene C. Behm, Kerri R. Beckmann, Jane E. Dahlstrom, Yanping Zhang, Carolyn Cho, Robin Stuart-Harris, Paul Craft, Angela Rezo, John M. Buckingham
Abstract: <h4>Aim</h4>There is debate as to what constitutes an adequate excision margin to reduce the risk of locoregional recurrence (LRR) after breast cancer surgery. We have investigated the relationship between surgical margin distance and LRR in women with invasive breast cancer (IBC).<h4>Methods</h4>Tumour free margin distances were extracted from histopathology reports for women with IBC, treated by either breast conserving surgery or mastectomy, enrolled in the Breast Cancer Treatment Group Quality Assurance Project from July 1997 to June 2007. Cox proportional hazards regression analyses were conducted to compare the risk of LRR for involved margins compared with negative margins, measured in increments rounded to the nearest mm.<h4>Results</h4>88 of 2300 patients (3.8%) experienced an LRR after a mean follow-up of 7.9 years. An involved margin, or a margin of 1 mm was associated with an increased risk of LRR (HR 2.72, 95% CI 1.30-5.69), whilst margin distances of 2 mm or greater were not. Risk of LRR with margin distances <2 mm was particularly high amongst those not receiving radiotherapy (RT).<h4>Conclusion</h4>Based on our findings, we recommend that a tumour free margin distance of 2 mm be adopted as an adequate margin of excision for IBC, in the setting of patients receiving standard adjuvant RT and adjuvant drug therapies as dictated by the current clinical treatment paradigms.
Keywords: Invasive breast cancer
Excision margins
Recurrence
Breast Cancer Treatment Group
Surgery
Pathology
Rights: Crown Copyright © 2013 Published by Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.breast.2013.02.018
Published version: http://dx.doi.org/10.1016/j.breast.2013.02.018
Appears in Collections:Aurora harvest
Public Health publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.