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Type: Journal article
Title: Long-term effects on offspring of exposure of oocytes and embryos to chemical and physical agents
Author: Walker, S.
Hartwich, K.
Robinson, J.
Citation: Human Reproduction Update, 2000; 6(6):564-577
Publisher: Oxford Univ Press
Issue Date: 2000
ISSN: 1355-4786
Abstract: Central to this review is the knowledge that, in some livestock species, the environment in which fertilization and embryo development occurs influences not only preimplantation embryo development but also the phenotype of resulting offspring. This knowledge is based on in-vitro studies where the induced changes in the embryo can result in an array of developmental abnormalities after transfer including fetal overgrowth. Whilst such findings are of immediate relevance to assisted reproduction in the human, they also raise another equally important but less obvious issue. Can the in-vivo environments in which fertilization and embryo development normally occur be influenced by exogenous factors (either physical or chemical) in such a way that long-term development is adversely affected? In a global environment of increased use of synthetic chemicals and increased production of pollutants, it is an issue of growing relevance. This review examines technical information that is pertinent to these issues together with a brief assessment of some possible molecular mechanisms responsible for aberrant development. The review concludes with an assessment of the clinical significance of the findings.
Keywords: Oocytes
Prenatal Exposure Delayed Effects
Radiation Injuries
Environmental Pollutants
Reproductive Techniques
Embryo, Mammalian
DOI: 10.1093/humupd/6.6.564
Appears in Collections:Aurora harvest 4
Obstetrics and Gynaecology publications

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