Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/82470
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Type: Journal article
Title: Rapid increase in pertactin-deficient Bordetella pertussis isolates, Australia
Author: Lam, C.
Marshall, H.
Citation: Emerging Infectious Diseases, 2014; 20(4):626-633
Publisher: Centers for Disease Control and Prevention
Issue Date: 2014
ISSN: 1080-6059
1080-6059
Statement of
Responsibility: 
Connie Lam, Sophie Octavia, Lawrence Ricafort, Vitali Sintchenko, Gwendolyn L. Gilbert, Nicholas Wood, Peter McIntyre, Helen Marshall, Nicole Guiso, Anthony D. Keil, Andrew Lawrence, Jenny Robson, Geoff Hogg, and Ruiting Lan
Abstract: Acellular vaccines against Bordetella pertussis were introduced in Australia in 1997. By 2000, these vaccines had replaced whole-cell vaccines. During 2008–2012, a large outbreak of pertussis occurred. During this period, 30% (96/320) of B. pertussis isolates did not express the vaccine antigen pertactin (prn). Multiple mechanisms of prn inactivation were documented, including IS481 and IS1002 disruptions, a variation within a homopolymeric tract, and deletion of the prn gene. The mechanism of lack of expression of prn in 16 (17%) isolates could not be determined at the sequence level. These findings suggest that B. pertussis not expressing prn arose independently multiple times since 2008, rather than by expansion of a single prn-negative clone. All but 1 isolate had ptxA1, prn2, and ptxP3, the alleles representative of currently circulating strains in Australia. This pattern is consistent with continuing evolution of B. pertussis in response to vaccine selection pressure.
Keywords: Bordetella pertussis
Whooping Cough
Pertussis Toxin
Bacterial Outer Membrane Proteins
Virulence Factors, Bordetella
Pertussis Vaccine
Antigens, Bacterial
Alleles
Australia
Rights: Public Domain as per Centers for Disease Control and Prevention [U.S. Government]
DOI: 10.3201/eid2004.131478
Grant ID: http://purl.org/au-research/grants/nhmrc/1011942
Appears in Collections:Aurora harvest
Paediatrics publications

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